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. 2020 Dec 14:7:592921.
doi: 10.3389/fmed.2020.592921. eCollection 2020.

Effect of Human Chorionic Gonadotropin Injection Before Frozen Embryo Transfer on Pregnancy Outcomes in Endometriosis-Associated Infertility

Yanbo Du  1 , Lei Yan  1   2   3 , Mei Sun  1   4 , Yan Sheng  1   4 , Xiufang Li  1 , Zhenhua Feng  1 , Rong Tang  1   4
Affiliations

Effect of Human Chorionic Gonadotropin Injection Before Frozen Embryo Transfer on Pregnancy Outcomes in Endometriosis-Associated Infertility

Yanbo Du et al. Front Med (Lausanne). .

Abstract

Purpose: The aim of this study was to investigate the effect of human chorionic gonadotropin (hCG) in hormone replacement (HT) regime for frozen thawed embryo transfer in women with endometriosis (EM). Methods: We performed a retrospective, database-search, cohort study and included data on EM patients who underwent frozen embryo transfer (FET) between January 1, 2009 and August 31, 2018. According to the protocols for FET cycle, the patients were divided into two groups: control group (n = 296) and hCG group (n = 355). Clinical pregnancy rate, live birth rate, early abortion rate, late abortion rate, and ectopic pregnancy rate were compared between the two groups. Results: There was a significant increase in clinical pregnancy rate in the hCG group (57.7 vs. 49%, p = 0.027) compared with the control group. The live birth rate in the hCG group (45.6 vs. 38.5%, p = 0.080) was also elevated, but this difference was not statistically significant. Conclusion: hCG administration in HT regime for FET increases the pregnancy rate in women with EM.

Keywords: assisted reproductive technology; endometriosis; frozen embryo transfer; hormone replacement; human chorionic gonadotropin.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

    1. Senapati S, Sammel MD, Morse C, Barnhart KT. Impact of endometriosis on in vitro fertilization outcomes: an evaluation of the Society for Assisted Reproductive Technologies Database. Fertil Steril. (2016) 106:164–71 e1. 10.1016/j.fertnstert.2016.03.037 - DOI - PMC - PubMed
    1. Johnson NP, Hummelshoj L. Consensus on current management of endometriosis. Hum Reprod. (2013) 28:1552–68. 10.1093/humrep/det050 - DOI - PubMed
    1. Meuleman C, Vandenabeele B, Fieuws S, Spiessens C, Timmerman D, D'Hooghe T. High prevalence of endometriosis in infertile women with normal ovulation and normospermic partners. Fertil Steril. (2009) 92:68–74. 10.1016/j.fertnstert.2008.04.056 - DOI - PubMed
    1. Du YB, Gao MZ, Shi Y, Sun ZG, Wang J. Endocrine and inflammatory factors and endometriosis-associated infertility in assisted reproduction techniques. Arch Gynecol Obstet. (2013) 287:123–30. 10.1007/s00404-012-2567-0 - DOI - PubMed
    1. Miller JE, Ahn SH, Monsanto SP, Khalaj K, Koti M, Tayade C. Implications of immune dysfunction on endometriosis associated infertility. Oncotarget. (2017) 8:7138–47. 10.18632/oncotarget.12577 - DOI - PMC - PubMed

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