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Observational Study
. 2021 Jul;9(4):910-915.
doi: 10.1016/j.jvsv.2020.12.074. Epub 2020 Dec 28.

Hypersensitivity reaction after cyanoacrylate closure of incompetent saphenous veins in patients with chronic venous disease: A retrospective study

Nuttawut Sermsathanasawadi  1 , Pak Hanaroonsomboon  1 , Kanin Pruekprasert  1 , Tossapol Prapassaro  1 , Nattawut Puangpunngam  1 , Kiattisak Hongku  1 , Suteekhanit Hahtapornsawan  1 , Khamin Chinsakchai  1 , Chumpol Wongwanit  1 , Chanean Ruangsetakit  2
Affiliations
Observational Study

Hypersensitivity reaction after cyanoacrylate closure of incompetent saphenous veins in patients with chronic venous disease: A retrospective study

Nuttawut Sermsathanasawadi et al. J Vasc Surg Venous Lymphat Disord. 2021 Jul.

Abstract

Purpose: The objective of this study was to evaluate the incidence of, the risk factors for, the nature of the disease, and the management of hypersensitivity reaction (HSR) after cyanoacrylate closure (CAC) of incompetent saphenous veins in patients with chronic venous disease.

Methods: Data consisting of all incompetent saphenous veins, including great saphenous veins, anterior accessory saphenous veins, and small saphenous veins, treated with CAC at Siriraj Hospital (Bangkok, Thailand) from January 2017 to December 2018 were retrospectively evaluated.

Results: A total of 126 saphenous veins, including 106 great saphenous veins (84.1%), 7 anterior accessory saphenous veins (5.6%), and 13 small saphenous veins (10.3%) of 126 limbs from 101 patients were included. A HSR occurred in 16 of 101 patients (15.8%), in 19 of 126 limbs (15.0%), and in 19 of 126 treated saphenous veins (15.0%). HSR-related erythema, itching, swelling, and pain occurred in 100.0%, 95.0%, 68.4%, and 52.6%, of HSR patients, respectively. HSR occurred 1 week after CAC. All HSR symptoms were mild, could be treated with nonsteroidal anti-inflammatory drugs (NSAIDs) and antihistamine, and were resolved within 1 week. The risk factors for HSR were suprafascial saphenous vein with a depth <1 cm from the skin, and saphenous vein diameter of ≥8 mm.

Conclusions: A HSR occurred in 15.8% of patients and in 15.0% of limbs after CAC. Risk factors for HSR were a suprafascial saphenous vein located close to the skin and a large saphenous vein. All HSR symptoms were mild in severity, occurred at 1 week after CAC, and were resolved within 1 week after treatment with nonsteroidal anti-inflammatory drugs and antihistamines. To prevent HSR, CAC should be avoided in suprafascial saphenous veins that are located close to the skin, and CAC in saphenous veins with a size of ≥8 mm should be performed with caution.

Keywords: Chronic venous disease; Cyanoacrylates; Hypersensitivity reaction; Phlebitis-like abnormal reaction; Varicose vein.

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Comment in

  • Cyanoacrylate-induced delayed hypersensitivity is different from chemical inflammation.
    Wilczko J, Szary C, Grzela T. Wilczko J, et al. J Vasc Surg Venous Lymphat Disord. 2021 Sep;9(5):1351-1352. doi: 10.1016/j.jvsv.2021.06.014. J Vasc Surg Venous Lymphat Disord. 2021. PMID: 34399944 No abstract available.
  • Reply.
    Sermsathanasawadi N, Pruekprasert K. Sermsathanasawadi N, et al. J Vasc Surg Venous Lymphat Disord. 2021 Sep;9(5):1352. doi: 10.1016/j.jvsv.2021.06.013. J Vasc Surg Venous Lymphat Disord. 2021. PMID: 34399945 No abstract available.

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