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. 1988 Jan;33(1):19-22.
doi: 10.1007/BF01536625.

Effect of cholecystectomy on mouth-to-cecum transit of a liquid meal

R Penagini  1 , R C Spiller, J J Misiewicz, P G Frost, D B Silk
Affiliations

Effect of cholecystectomy on mouth-to-cecum transit of a liquid meal

R Penagini et al. Dig Dis Sci. 1988 Jan.

Abstract

Mouth-to-cecum transit and serum bile acid profile after ingestion of a lactulose-labeled liquid meal (440 kcal) were measured in eight patients with gallstones and a radiologically functioning gallbladder before and three to five months after cholecystectomy and in 15 controls. In the patients mouth-to-cecum transit was longer after the operation, 87.5 +/- 18.5 (mean +/- SEM) min vs 57.5 +/- 9.7 min (P less than 0.05). Mouth-to-cecum transit times before and after the operation were not different from controls (58.0 +/- 6.7 min). Serum bile acid AUCs were similar (P = NS) in patients and controls, while total bile acid and cholylglycine fasting concentrations were higher after cholecystectomy (P less than 0.05 and P less than 0.01 respectively). Cholecystectomy prolongs mouth-to-cecum transit of a liquid meal.

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