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. 2021 Feb:181:106131.
doi: 10.1016/j.mimet.2020.106131. Epub 2020 Dec 30.

A novel bioreactor for the stable growth of Ureaplasma parvum and Ureaplasma urealyticum

Derek Fleming  1 , Melissa Karau  1 , Robin Patel  2
Affiliations

A novel bioreactor for the stable growth of Ureaplasma parvum and Ureaplasma urealyticum

Derek Fleming et al. J Microbiol Methods. 2021 Feb.

Abstract

Ureaplasma species, including Ureaplasma parvum and Ureaplasma urealyticum, are challenging to culture and maintain. Here, we describe a novel bioreactor for growing high-titer liquid Ureaplasma cultures in a stable manner.

Keywords: Bioreactor; Culture; Growth; Ureaplasma; Ureaplasma parvum.

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Conflict of interest statement

Conflict of Interests: Dr. Patel reports grants from Merck, ContraFect, TenNor Therapeutics Limited and Shionogi. Dr. Patel is a consultant to Curetis, Specific Technologies, Next Gen Diagnostics, PathoQuest, Selux Diagnostics, 1928 Diagnostics, PhAST, and Qvella; monies are paid to Mayo Clinic. Dr. Patel is also a consultant to Netflix. In addition, Dr. Patel has a patent on Bordetella pertussis/parapertussis PCR issued, a patent on a device/method for sonication with royalties paid by Samsung to Mayo Clinic, and a patent on an anti-biofilm substance issued. Dr. Patel receives an editor’s stipend from IDSA, and honoraria from the NBME, Up-to-Date and the Infectious Diseases Board Review Course.

Figures

Figure 1.
Figure 1.
Schematic of the Ureaplasma reactor.
See this image and copyright information in PMC

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