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Comment
. 2021 Aug;60(8):937-938.
doi: 10.1016/j.jaac.2020.09.025. Epub 2020 Dec 29.

Treating Autism With Bumetanide: Are Large Multicentric and Monocentric Trials on Selected Populations Complementary?

Eric Lemonnier  1 , Hamed Rabiei  2 , David Makowski  3 , Nouchine Hadjikhani  4 , Yehezkel Ben-Ari  5
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Treating Autism With Bumetanide: Are Large Multicentric and Monocentric Trials on Selected Populations Complementary?

Eric Lemonnier et al. J Am Acad Child Adolesc Psychiatry. 2021 Aug.

Abstract

In their article in the Journal, Sprengers et al.1 conclude that bumetanide does not attenuate autism spectrum disorder (ASD) despite a nominally significant treatment effect in repetitive behaviors, which is a core symptom of ASD but was defined as a secondary measure in this trial. Four earlier studies performed by 3 independent institutes, including 2 studies2,3 not mentioned by Sprengers et al., testing a total of 169 children (versus 122 placebo) showed a significant amelioration of ASD symptoms. Bumetanide also significantly attenuated behavioral features of patients with tuberous sclerosis according to another study by Sprengers' same group.4.

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  • Dr. Sprengers et al. Reply.
    Sprengers JJ, van Andel DM, Bruining H. Sprengers JJ, et al. J Am Acad Child Adolesc Psychiatry. 2021 Aug;60(8):938-939. doi: 10.1016/j.jaac.2020.12.034. Epub 2021 Jan 12. J Am Acad Child Adolesc Psychiatry. 2021. PMID: 33450401

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