Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Mar;28(2):390-397.
doi: 10.1111/odi.13765. Epub 2021 Feb 2.

Helicobacter pylori and other factors in recurrent aphthous stomatitis: A cross-sectional study

Daniel Schebela Mazzoleni  1 , Felipe Mazzoleni  1   2 , Luiz Edmundo Mazzoleni  1   3   4 , Carlos Fernando de Magalhães Francesconi  1   3   4 , Tobias Cancian Milbradt  1   5 , Diego Mendonça Uchoa  6 , Heitor Ribeiro Birnfeld  7 , Luiza Vitelo Andrighetto  1 , Sacha Allebrandt da Silva Ries  8 , Daniel Simon  9 , Nicholas Joseph Talley  10
Affiliations

Helicobacter pylori and other factors in recurrent aphthous stomatitis: A cross-sectional study

Daniel Schebela Mazzoleni et al. Oral Dis. 2022 Mar.

Abstract

Objectives: To evaluate the role of Helicobacter pylori and other risk factors in recurrent aphthous stomatitis (RAS).

Methods: Patients with functional dyspepsia responded to questionnaires regarding demographic and clinical data, anxiety and depression, and a specific RAS questionnaire. They underwent upper digestive endoscopy and H. pylori evaluation.

Results: 476 patients were included and of the 372 evaluated for H. pylori, 65.6% were H. pylori-positive. RAS was reported by 32.6% (155/476). In the bivariate analysis of the 372 patients evaluated for gastric H. pylori status, positive subjects had a lower RAS prevalence (29.9%; 73/244) than H. pylori-negative (41.4%; 53/128) (p = .026). Smoking (p = .005) and older age (p = .034) were also associated with a lower prevalence, while female gender (p = .032) and lower income (p = .046) presented higher RAS prevalence. In the multivariate analysis, H. pylori infection (p = .017), smoking (p = .001), and older age (p = .013) were protective factors, while lower income (p = .030) and anxiety (p = .042) were risk factors. In the multivariate analysis of all patients, female gender, lower income, and more schooling years were risk factors.

Conclusions: An unexpected lower prevalence of RAS was found in H. pylori-positive patients. Smoking, sex, age, income, education, and anxiety were associated with RAS.

Keywords: age groups; anxiety; dyspepsia; educational status; income; risk factors; smoking; socioeconomic factors.

PubMed Disclaimer

References

REFERENCES

    1. Adler, I., Muiño, A., Aguas, S., Harada, L., Diaz, M., Lence, A., Labbrozzi, M., Muiño, J. M., Elsner, B., Avagnina, A., & Denninghoff, V. (2014). Helicobacter pylori and oral pathology: Relationship with the gastric infection. World Journal of Gastroenterology, 20(29), 9922-9935. https://doi.org/10.3748/wjg.v20.i29.9922
    1. Afghari, P., Khazaei, S., Kazemi, S., Savabi, O., Keshteli, A. H., & Adibi, P. (2011). The role of Helicobacter pylori in the development of recurrent aphthous stomatitis: SEPAHAN systematic review no. 9. Dental Research Journal, 8(Suppl 1), S2-S8.
    1. Akintoye, S. O., & Greenberg, M. S. (2005). Recurrent aphthous stomatitis. Dental Clinics of North America, 49(1), 31-47. https://doi.org/10.1016/j.cden.2004.08.001
    1. Albanidou-Farmaki, E., Giannoulis, L., Markopoulos, A., Fotiades, S., Aggouridaki, X., Farmakis, K., & Papanayotou, P. (2005). Outcome following treatment for Helicobacter pylori in patients with recurrent aphthous stomatitis. Oral Diseases, 11(1), 22-26. https://doi.org/10.1111/j.1601-0825.2004.01053.x
    1. Albanidou-Farmaki, E., Poulopoulos, A. K., Epivatianos, A., Farmakis, K., Karamouzis, M., & Antoniades, D. (2008). Increased anxiety level and high salivary and serum cortisol concentrations in patients with recurrent aphthous stomatitis. Tohoku Journal of Experimental Medicine, 214(4), 291-296. https://doi.org/10.1620/tjem.214.291

LinkOut - more resources