Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2021 Feb;303(2):363-379.
doi: 10.1007/s00404-020-05903-w. Epub 2021 Jan 2.

A systematic review and meta-analysis on the prevalence of Escherichia coli and extended-spectrum β-lactamase-producing Escherichia coli in pregnant women

Yousef Moradi  1   2 , Babak Eshrati  3 , Seyed Abbas Motevalian  1 , Ali Majidpour  4 , Hamid Reza Baradaran  5   6
Affiliations
Meta-Analysis

A systematic review and meta-analysis on the prevalence of Escherichia coli and extended-spectrum β-lactamase-producing Escherichia coli in pregnant women

Yousef Moradi et al. Arch Gynecol Obstet. 2021 Feb.

Abstract

Propose: The aim of the present study was to determine the prevalence of E. coli and extended-spectrum β-lactamase-producing (ESBL) E. coli in pregnant women in a systematic review and meta-analysis study.

Methods: We searched important databases, including Medline (PubMed), Embase, Scopus, Web of sciences, Cochrane library, Ovid, and CINHAL to retrieve all articles reporting the prevalence of ESBL E. coli in pregnant women that published from January 1990 to June 2020.

Results: The pooled prevalence of E. coli in pregnant women with and without symptoms of UTI after combining 82 studies with a sample size of 33,118 was 29% (29%; %95 CI 23, 36%). The prevalence based on urine, Feacal, and vagina samples was 26% (% 95 CI 19-34%), 77% (% 95 CI 22-98%), and 32% (% 95 CI 17-48%), respectively. Also, 19 studies with a sample size of 9,200 reported ESBL E. coli prevalence in pregnant women. After combining the results of these studies, the pooled prevalence of ESBL E. coli in pregnant women was 34% (34%; %95 CI 24, 43%). The pooled prevalence of E. coli in pregnant women with HIV was 9%(9%; %95 CI 7, 11%).

Conclusion: According to the results of this study, the prevalence of E. coli and ESBL E. coli is high in pregnant women. Also, the overuse of antibiotics was higher in European and Asian pregnant women than other continents.

Keywords: Escherichia coli; Extended spectrum β-lactamase producing; Meta-analysis; Pregnant women.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Delzell JE Jr, Lefevre M (2000) Urinary tract infections during pregnancy. Am Fam Physician 61(3):713–720 - PubMed
    1. Duarte G, Marcolin AC, Quintana SM, Cavalli RC (2008) Urinary tract infection in pregnancy. Revista Brasileira de Ginecologia e Obstetricia 30(2):93–10 - DOI
    1. Masinde A, Gumodoka B, Kilonzo A, Mshana S (2009) Prevalence of urinary tract infection among pregnant women at Bugando Medical Centre, Mwanza, Tanzania. Tanzania J Health Res 11(3):154–159 - DOI
    1. Blomberg B, Olsen BE, Hinderaker SG, Langeland N, Gasheka P, Jureen R, Kvåle G, Midtvedt T (2005) Antimicrobial resistance in urinary bacterial isolates from pregnant women in rural Tanzania: implications for public health. Scand J Infect Dis 37(4):262–268 - DOI
    1. Gaougaou G, Shankar S, Liot Q, Constant P, Déziel E, Lacroix M (2020) Gamma irradiation triggers a global stress response in Escherichia coli O157: H7 including base and nucleotides excision repair pathways. Microb Pathog 149(1):104–150

LinkOut - more resources