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Review
. 2021 Feb;26(1-2):9-23.
doi: 10.1007/s10495-020-01649-7. Epub 2021 Jan 2.

The role of the DFF40/CAD endonuclease in genomic stability

Merve Kulbay  1   2 , Nathan Bernier-Parker  3 , Jacques Bernier  4
Affiliations
Review

The role of the DFF40/CAD endonuclease in genomic stability

Merve Kulbay et al. Apoptosis. 2021 Feb.

Abstract

Maintenance of genomic stability in cells is primordial for cellular integrity and protection against tumor progression. Many factors such as ultraviolet light, oxidative stress, exposure to chemical reagents, particularly mutagens and radiation, can alter the integrity of the genome. Thus, human cells are equipped with many mechanisms that prevent these irreversible lesions in the genome, as DNA repair pathways, cell cycle checkpoints, and telomeric function. These mechanisms activate cellular apoptosis to maintain DNA stability. Emerging studies have proposed a new protein in the maintenance of genomic stability: the DNA fragmentation factor (DFF). The DFF40 is an endonuclease responsible of the oligonucleosomal fragmentation of the DNA during apoptosis. The lack of DFF in renal carcinoma cells induces apoptosis without oligonucleosomal fragmentation, which poses a threat to genetic information transfer between cancerous and healthy cells. In this review, we expose the link between the DFF and genomic instability as the source of disease development.

Keywords: Apoptosis; Cancer cell resistance; DFF40; Genomic stability.

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References

    1. Kerr JF, Wyllie AH, Currie AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26(4):239–257 - PubMed - PMC - DOI
    1. Compton MM (1992) A biochemical hallmark of apoptosis: internucleosomal degradation of the genome. Cancer Metastasis Rev 11(2):105–119 - PubMed - DOI
    1. Saraste A, Pulkki K (2000) Morphologic and biochemical hallmarks of apoptosis. Cardiovasc Res 45(3):528–537 - PubMed - DOI
    1. Nair P, Lu M, Petersen S, Ashkenazi A (2014) Apoptosis initiation through the cell-extrinsic pathway. Methods Enzymol 544:99–128. https://doi.org/10.1016/b978-0-12-417158-9.00005-4 - DOI - PubMed
    1. Elmore S (2007) Apoptosis: a review of programmed cell death. Toxicol Pathol 35(4):495–516. https://doi.org/10.1080/01926230701320337 - DOI - PubMed - PMC

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