Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Sep;20(9):2750-2752.
doi: 10.1111/jocd.13930. Epub 2021 Jan 19.

Xanthelasma palpebrarum after hyaluronic acid injection in the lower eyelid: A case report and review of the literature

Vivian Simões Pires  1 , Isabella Osorio Wender  2 , Manoella Freitas Santos  1 , Gabriela Lorentz Sartori  1   3 , Analú Vivian  1 , Gabriela Dallagnese  1
Affiliations
Review

Xanthelasma palpebrarum after hyaluronic acid injection in the lower eyelid: A case report and review of the literature

Vivian Simões Pires et al. J Cosmet Dermatol. 2021 Sep.

Abstract

Background: Hyaluronic acid filler treatments are a very popular nonsurgical procedure worldwide, most wanted to create a more attractive profile and correct facial aging. Since its usage has expanded, more complications have been seen.

Aims: To report a probably new adverse effect related to injectable fillers.

Patient: A 38-year-old white woman who underwent hyaluronic acid filling in the periorbital area and presented twelve months after with two symmetrically yellowish plaque lesions on the lower eyelids, with no edema or nodules.

Results: The lesion appeared to be xanthelasma, in a patient with no history of hyperlipidemia. Histological analysis showed unspecific findings with rare histiocytes present in the papillary dermis. The patient was treated with hyaluronidase infiltration in both lower eyelid areas as an attempt to minimize the appearance of the lesions, with a satisfactory response.

Conclusions: As hyaluronic acid fillings are becoming more popular, all physicians have to be aware of its complications. The xanthelasma-like reaction is probably a new adverse effect related to injectable fillers and it is important to be alert to this possibility.

Keywords: adverse effect; dermal fillers; eyelid; hyaluronic acid; xanthelasma.

PubMed Disclaimer

References

REFERENCES

    1. D’Acunto C, Pazzaglia M, Raone B, Misciali, C, et al. Xanthelasma palpebrarum: a new adverse reaction to intradermal fillers? Br J Dermatol. 2013;168(2):437-439.
    1. Carvalho GG, Alves MFDM, Morett VH, et al. The use of hyaluronic acid and polymethylmethacrylate in the skin aging process in a comparative analysis (the advantages, disadvantages and adverse effects of each filler). Int J Advan Eng Res Sci. 2020;7(2):50-59.
    1. Kim JE, Sykes JM. Hyaluronic acid fillers: history and overview. Facial Plast Surg. 2011;27(6):523-528.
    1. Koh IS, Lee W, eds. Hyaluronic acid filler and hyaluronidase. In: Filler Complications. Singapore: Springer; 2019:27-40.
    1. Abduljabbar MH, Basendwh MA. Complications of hyaluronic acid fillers and their managements. J Dermatol Dermatol Surg. 2016;20:10-106.

LinkOut - more resources