Review
doi: 10.1007/978-1-4757-9113-6_36.
Chemical basis for pharmacological and therapeutic actions of penicillamine
- PMID: 333874
- DOI: 10.1007/978-1-4757-9113-6_36
Item in Clipboard
Review
Chemical basis for pharmacological and therapeutic actions of penicillamine
Adv Exp Med Biol.
1977.
Abstract
The pharmacological and therapeutic action of penicillamine are very largely explained by its ability to chelate metal ions and take part in oxidation-reduction reactions, sulfhydryl-disulfide interchange, and nucleophilic addition. Effects of penicillamine on particular enzymes are explained by its chemical properties. Possible interactions with amino acids, tissue proteins, food constituents, and intermediates in the metabolism and biosynthesis of sulfur containing amino acids are discussed.
Similar articles
-
Chemical basis for pharmacological and therapeutic actions of penicillamine.Proc R Soc Med. 1977;70 Suppl 3(Suppl 3):50-60. doi: 10.1177/00359157770700S320. Proc R Soc Med. 1977. PMID: 122675 Free PMC article. Review. No abstract available.
-
CURRENT THERAPEUTICS. 192. PENICILLAMINE.Practitioner. 1963 Dec;191:789-95. Practitioner. 1963. PMID: 14084387 No abstract available.
-
Biologically oriented organic sulfur chemistry. 8. Structure-activity relationships of penicillamine analogs and derivatives.J Med Chem. 1971 Sep;14(9):868-72. doi: 10.1021/jm00291a024. J Med Chem. 1971. PMID: 5140016 No abstract available.
-
Therapeutic uses of copper-chelating agents.Ciba Found Symp. 1980;79:283-99. Ciba Found Symp. 1980. PMID: 6907089
-
Penicillamine and analogous chelating agents.Ann N Y Acad Sci. 1971 Jul 6;179:481-6. doi: 10.1111/j.1749-6632.1971.tb46924.x. Ann N Y Acad Sci. 1971. PMID: 4399397 Review. No abstract available.
Cited by
-
Metabolic turnover of cysteine-related thiol compounds at environmentally relevant concentrations by Geobacter sulfurreducens.Front Microbiol. 2023 Jan 11;13:1085214. doi: 10.3389/fmicb.2022.1085214. eCollection 2022. Front Microbiol. 2023. PMID: 36713222 Free PMC article.
-
The Role of Sulfhydryl (Thiols) Groups in Oral and Periodontal Diseases.Biomedicines. 2024 Apr 16;12(4):882. doi: 10.3390/biomedicines12040882. Biomedicines. 2024. PMID: 38672236 Free PMC article.
-
D-Penicillamine-Induced Stevens-Johnson Syndrome in a Patient with Gold Cyanide Intoxication: A Case Report.Clin Cosmet Investig Dermatol. 2024 Oct 28;17:2409-2415. doi: 10.2147/CCID.S489028. eCollection 2024. Clin Cosmet Investig Dermatol. 2024. PMID: 39494039 Free PMC article.
-
Arsenic intoxication: general aspects and chelating agents.Arch Toxicol. 2020 Jun;94(6):1879-1897. doi: 10.1007/s00204-020-02739-w. Epub 2020 May 9. Arch Toxicol. 2020. PMID: 32388818 Free PMC article. Review.