Comment

. 2021 Apr;82(4):e20-e22.

doi: 10.1016/j.jinf.2020.12.026. Epub 2020 Dec 31.

Developing a multivariable risk prediction model to predict prolonged viral clearance in patients with COVID-19

Ying Liu¹, Min Li², Dan Liu³, Jian Fei Luo⁴, Nian Li⁵, Xuan Zhang³, Xiao Ju Tang⁶, Xin Zhang¹, Jia Liu⁷, Ji Wang⁷, Ting Wang⁷, Yong Zao Zhou⁷, Wen Xin Luo⁷, Zong An Liang⁸, Feng Ming Luo⁹, Wei Min Li¹⁰, Gang Wang¹¹

Affiliations

¹ Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China; Laboratory of Pulmonary Immunology and inflammation, Frontiers Science Center for Disease-related Molecular Network, Sichuan University, Chengdu 610041, PR China; Pneumology Group, Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China.
² Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China; Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Kunming Medical University, Kunming 650032, PR China.
³ Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China.
⁴ Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan 430022, Hubei, PR China.
⁵ Department of Medical Affairs, West China Hospital, Sichuan University, Chengdu 610041, PR China.
⁶ Laboratory of Pulmonary Immunology and inflammation, Frontiers Science Center for Disease-related Molecular Network, Sichuan University, Chengdu 610041, PR China.
⁷ Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China; Laboratory of Pulmonary Immunology and inflammation, Frontiers Science Center for Disease-related Molecular Network, Sichuan University, Chengdu 610041, PR China.
⁸ Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China. Electronic address: liang.zongan@163.com.
⁹ Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China; Laboratory of Pulmonary Immunology and inflammation, Frontiers Science Center for Disease-related Molecular Network, Sichuan University, Chengdu 610041, PR China. Electronic address: luofengming@hotmail.com.
¹⁰ Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China. Electronic address: weimi003@scu.edu.cn.
¹¹ Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China; Laboratory of Pulmonary Immunology and inflammation, Frontiers Science Center for Disease-related Molecular Network, Sichuan University, Chengdu 610041, PR China. Electronic address: wcums-respiration@hotmail.com.

PMID: 33387568
PMCID: PMC7773527
DOI: 10.1016/j.jinf.2020.12.026

Comment

Developing a multivariable risk prediction model to predict prolonged viral clearance in patients with COVID-19

Ying Liu et al. J Infect. 2021 Apr.

. 2021 Apr;82(4):e20-e22.

doi: 10.1016/j.jinf.2020.12.026. Epub 2020 Dec 31.

Authors

Affiliations

¹ Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China; Laboratory of Pulmonary Immunology and inflammation, Frontiers Science Center for Disease-related Molecular Network, Sichuan University, Chengdu 610041, PR China; Pneumology Group, Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China.
² Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China; Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Kunming Medical University, Kunming 650032, PR China.
³ Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China.
⁴ Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan 430022, Hubei, PR China.
⁵ Department of Medical Affairs, West China Hospital, Sichuan University, Chengdu 610041, PR China.
⁶ Laboratory of Pulmonary Immunology and inflammation, Frontiers Science Center for Disease-related Molecular Network, Sichuan University, Chengdu 610041, PR China.
⁷ Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China; Laboratory of Pulmonary Immunology and inflammation, Frontiers Science Center for Disease-related Molecular Network, Sichuan University, Chengdu 610041, PR China.
⁸ Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China. Electronic address: liang.zongan@163.com.
⁹ Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China; Laboratory of Pulmonary Immunology and inflammation, Frontiers Science Center for Disease-related Molecular Network, Sichuan University, Chengdu 610041, PR China. Electronic address: luofengming@hotmail.com.
¹⁰ Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China. Electronic address: weimi003@scu.edu.cn.
¹¹ Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China; Laboratory of Pulmonary Immunology and inflammation, Frontiers Science Center for Disease-related Molecular Network, Sichuan University, Chengdu 610041, PR China. Electronic address: wcums-respiration@hotmail.com.

PMID: 33387568
PMCID: PMC7773527
DOI: 10.1016/j.jinf.2020.12.026

No abstract available

Keywords: COVID-19; Prediction model; SARS-CoV-2; Viral clearance.

PubMed Disclaimer

Conflict of interest statement

Declaration of Competing Interest All of the authors have no conflict of interest.

Figures

Fig 1 — **Fig. 1**
Selection of potential predictors of the mode applying the LASSO regression analysis. (A) LASSO coefficient profiles of the potential included predictors. The coefficient profile plot was produced against the log(lambda) sequence. (B) Befitting λ selection in the LASSO regression analysis based on the 5-fold cross-validation. Partial likelihood deviance (binomial deviance) curve was plotted versus log (λ). Dotted vertical lines were drawn based on the minimum criteria and 1 standard error of the minimum criteria (the 1-SE criteria).

Fig 2 — **Fig. 2**
Nomogram for predicting prolonged SARS-CoV-2 RNA clearance risk. The score of each predictors were added to obtain the total score and a vertical line was drawn on the total score to obtain the corresponding possibility of SARS-CoV-2 RNA prolonged shedding.

See this image and copyright information in PMC

Comment on

SARS-CoV-2 detection, viral load and infectivity over the course of an infection.
Walsh KA, Jordan K, Clyne B, Rohde D, Drummond L, Byrne P, Ahern S, Carty PG, O'Brien KK, O'Murchu E, O'Neill M, Smith SM, Ryan M, Harrington P. Walsh KA, et al. J Infect. 2020 Sep;81(3):357-371. doi: 10.1016/j.jinf.2020.06.067. Epub 2020 Jun 29. J Infect. 2020. PMID: 32615199 Free PMC article.

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Developing a multivariable risk prediction model to predict prolonged viral clearance in patients with COVID-19

Affiliations

Developing a multivariable risk prediction model to predict prolonged viral clearance in patients with COVID-19

Authors

Affiliations

Conflict of interest statement

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