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Comment
. 2021 Apr:72:216-217.
doi: 10.1016/j.avsg.2020.12.006. Epub 2020 Dec 30.

The COVID-19 Arterial Thromboembolic Complications: From Inflammation to Immunothrombosis Through Antiphospholipid Autoantibodies

Luca Roncati  1 , Antonio Manenti  2 , Gianrocco Manco  3 , Alberto Farinetti  3 , Annavittoria Mattioli  4
Affiliations
Comment

The COVID-19 Arterial Thromboembolic Complications: From Inflammation to Immunothrombosis Through Antiphospholipid Autoantibodies

Luca Roncati et al. Ann Vasc Surg. 2021 Apr.
No abstract available

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Figures

Fig. 1
Fig. 1
Surgical specimen histopathology from a 72-year-old Italian male patient affected by severe COVID-19: (A) complete thrombosis of the medium-sized splenic artery [hematoxylin and eosin, x2.5 objective]: (B) neutrophils infiltration accompanied by karyorrhexis inside the tunica media and adventitia, a classical picture of “leukocytoclastic vasculitis”, with a still preserved endothelial layer [hematoxylin and eosin, x10 objective]; (C) immunohistochemistry for CD61 reveals platelets interaggregating and adhering to the endothelial cells (black arrows), together with occlusive microthromboses of vasa vasorum (red arrows) [2f2 clone, x10 objective]; (D) the platelets aggregates, adhering tenaciously to the endothelium, contain also blue-stained fibrin (blue arrows) [phosphotungstic acid hematoxylin, x10 objective].
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