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. 2021 Mar;232(3):332-338.
doi: 10.1016/j.jamcollsurg.2020.11.013. Epub 2020 Dec 30.

Getting Chemotherapy Directly to the Liver: The Historical Evolution of Hepatic Artery Chemotherapy

Roi Anteby  1 , Nancy E Kemeny  2 , T Peter Kingham  3 , Michael I D'Angelica  3 , Alice C Wei  3 , Vinod P Balachandran  3 , Jeffrey A Drebin  3 , Murray F Brennan  3 , Leslie H Blumgart  3 , William R Jarnagin  3
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Getting Chemotherapy Directly to the Liver: The Historical Evolution of Hepatic Artery Chemotherapy

Roi Anteby et al. J Am Coll Surg. 2021 Mar.
No abstract available

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Figures

Figure 1.
Figure 1.
External pump for ambulatory chemotherapy infusion. A patient with advanced metastatic adenocarcinoma of the liver receiving continuous ambulatory arterial cancer chemotherapy through a treatment catheter placed in the hepatic artery using a low volume portable pump apparatus. Reprinted from Sullivan, with permission.
Figure 2.
Figure 2.
Hepatic artery catherization achieved by inserting a catheter into the right gastroepiploic artery and threading it retrogradely into the hepatic artery. (A) An infuser device attached to a stump of the gastroepiploic artery supplies constant intrahepatic artery chemotherapy (illustration by Frank Henry Netter, reprinted with permission from Elsevier.).
Figure 3.
Figure 3.
Implantable infusion pump developed by Blackshear et al. in the 1970s (20-22). (A) Patient with a subcutaneous implanted drug pump. (B) Ex-vivo and in-vivo demonstration of an Infusaid drug infusion pump refill by injection, in 1983. The full 50 ml pump delivered fluid at a constant rate of 2.5-3 ml/day. Reprinted from Balch et al with permission.
Figure 4.
Figure 4.
Timeline with important achievements in hepatic artery chemotherapy and publication trends between the years 1950-1990. Annual publication entries in Medline (PubMed) for the terms: hepatic artery infusion chemotherapy.
See this image and copyright information in PMC

References

    1. Klopp CT, Alford TC, Bateman J, et al. Fractionated intra-arterial cancer: chemotherapy with methyl bis amine hydrochloride; a preliminary report. Annals of surgery. 1950;132(4):811. - PMC - PubMed
    1. Rhoads CP. Nitrogen mustards in the treatment of neoplastic disease: Official statement. Journal of the American Medical Association. 1946;131(8):656–8. - PubMed
    1. Bierman HR, Byron RL, Miller ER, Shimkin MB. Effects of intra-arterial administration of nitrogen mustard. The American journal of medicine. 1950;8(4):535. - PubMed
    1. Sullivan RD. Systemic and arterial infusion chemotherapy for metastatic liver cancer. International Journal of Radiation Oncology• Biology• Physics. 1976;1(9):973–6. - PubMed
    1. Sykes MP, Karnofsky DA, Philips FS, Burchenal JH. Clinical studies on triethylenephosphoramide and diethylenephosphoramide, compounds with nitrogen-mustard-like activity. Cancer. 1953;6(1):142–8.

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