The role of cytochrome P450-mediated detoxification in insect adaptation to xenobiotics
- PMID: 33387688
- DOI: 10.1016/j.cois.2020.11.004
The role of cytochrome P450-mediated detoxification in insect adaptation to xenobiotics
Abstract
Insect cytochrome P450 monooxygenases (P450s) are well known to be involved in metabolic detoxification of xenobiotics, such as phytochemicals, insecticides and environmental pollutants. Enhanced metabolic detoxification is closely associated with the constitutive overexpression and induction of P450s. In general, multiple insect P450s are co-responsible for xenobiotic detoxification. Considering the capacity of P450s to respond to a wide range of xenobiotics, synergistic interactions between natural and synthetic xenobiotics and P450-mediated cross-tolerance/resistance are ubiquitous. Recent studies have indicated that both transcription factors and signaling pathways are involved in the regulation of P450 genes in xenobiotic responses. This article reviews our current understanding of P450-mediated detoxification in insect adaptation to xenobiotics and highlights recent progress in the molecular basis of P450 regulation.
Copyright © 2020 Elsevier Inc. All rights reserved.
Similar articles
-
Heterologous expression of insect P450 enzymes that metabolize xenobiotics.Curr Opin Insect Sci. 2021 Feb;43:78-84. doi: 10.1016/j.cois.2020.10.011. Epub 2020 Nov 10. Curr Opin Insect Sci. 2021. PMID: 33186746 Review.
-
Regulation of insect P450s in response to phytochemicals.Curr Opin Insect Sci. 2021 Feb;43:108-116. doi: 10.1016/j.cois.2020.12.003. Epub 2020 Dec 29. Curr Opin Insect Sci. 2021. PMID: 33385580 Review.
-
The Role of Cytochrome P450s in Insect Toxicology and Resistance.Annu Rev Entomol. 2022 Jan 7;67:105-124. doi: 10.1146/annurev-ento-070621-061328. Epub 2021 Sep 30. Annu Rev Entomol. 2022. PMID: 34590892 Review.
-
Molecular mechanisms of metabolic resistance to synthetic and natural xenobiotics.Annu Rev Entomol. 2007;52:231-53. doi: 10.1146/annurev.ento.51.110104.151104. Annu Rev Entomol. 2007. PMID: 16925478 Review.
-
A Malpighian Tubule-Specific P450 Gene SlCYP9A75a Contributes to Xenobiotic Tolerance in Spodoptera litura.J Agric Food Chem. 2024 Jul 17;72(28):15624-15632. doi: 10.1021/acs.jafc.4c03069. Epub 2024 Jul 1. J Agric Food Chem. 2024. PMID: 38952111
Cited by
-
Omics approaches to unravel insecticide resistance mechanism in Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae).PeerJ. 2024 Sep 5;12:e17843. doi: 10.7717/peerj.17843. eCollection 2024. PeerJ. 2024. PMID: 39247549 Free PMC article. Review.
-
Identification and Characterization of CYP6 Family Genes from the Oriental Fruit Moth (Grapholita molesta) and Their Responses to Insecticides.Insects. 2022 Mar 17;13(3):300. doi: 10.3390/insects13030300. Insects. 2022. PMID: 35323597 Free PMC article.
-
Identification of the Flavone-Inducible Counter-Defense Genes and Their cis-Elements in Helicoverpa armigera.Toxins (Basel). 2023 May 29;15(6):365. doi: 10.3390/toxins15060365. Toxins (Basel). 2023. PMID: 37368666 Free PMC article.
-
Differential detoxification enzyme profiles in C-corn strain and R-rice strain of Spodoptera frugiperda by comparative genomic analysis: insights into host adaptation.BMC Genomics. 2025 Jan 6;26(1):14. doi: 10.1186/s12864-024-11185-2. BMC Genomics. 2025. PMID: 39762739 Free PMC article.
-
Physiological, molecular and histological response of Pentodon bispinosus larvae (Coleoptera: Scarabaeidae) as a novel bioindicator for soil pollutants.Sci Rep. 2025 Aug 25;15(1):31173. doi: 10.1038/s41598-025-15417-7. Sci Rep. 2025. PMID: 40855158 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources