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. 2021 Apr;52(2):135-152.
doi: 10.1007/s10735-020-09930-4. Epub 2021 Jan 3.

Polydatin and polydatin-loaded chitosan nanoparticles attenuate diabetic cardiomyopathy in rats

Fatma Mostafa  1 , Adel Abdel-Moneim  2 , Manal Abdul-Hamid  1 , Sanaa R Galaly  1 , Hanaa M Mohamed  3
Affiliations

Polydatin and polydatin-loaded chitosan nanoparticles attenuate diabetic cardiomyopathy in rats

Fatma Mostafa et al. J Mol Histol. 2021 Apr.

Retraction in

Abstract

Hyperglycemia is associated with impairment of heart function. The current study aimed to investigate the ameliorative effect of polydatin-loaded chitosan nanoparticles (PD-CSNPs), polydatin (PD) and metformin (MET) on diabetic cardiomyopathy in rats. Rats divided into six groups; normal-control, diabetic-control, diabetic + CSNPs (diabetic rats treated with 50 mg/kg blank chitosan nanoparticles), diabetic + PD-CSNPs (diabetic rats treated with PD-CSNPs equivalent to 50 mg/kg of polydatin), diabetic + PD (diabetic rats given 50 mg/kg polydatin), diabetic + MET (diabetic rats given 100 mg/kg metformin), orally and daily for 4 weeks. Treatment of diabetic rats with PD-CSNPs, PD and MET showed a significant reduction in the values of glucose and glycosylated hemoglobin with improvement in heart function biomarkers through decreasing serum creatine kinase and creatine kinase myocardial band activities compared to diabetic control. The treatment agents also suppressed the elevated lipid peroxidation product, increased values of glutathione content, superoxide dismutase, superoxide peroxidase, and catalase activities in the heart of diabetic treated rats. Furthermore, PD-CSNPs, PD and MET decreased heart tissue levels of a pro-inflammatory cytokine; tumor necrosis factor-alpha and nuclear factor-kappa β, upregulation of heart gene expressions; nuclear factor erythroid 2-related factor 2 and heme oxygenase-1. Histological and ultrastructural examinations revealed the ameliorative effect of PD-CSNPs, PD and MET against the harmful of diabetic cardiomyopathy by reducing the cardiac fibers, necrotic cardiac myocytes, inflammatory cell infiltration, and the arrangement of the myofibrils and intercalated discs. In conclusion, the new formula of PD-CSNPs was more effective than PD and MET in amelioration the diabetic cardiomyopathy through its antioxidant, anti-inflammatory and prolonged-release properties.

Keywords: Diabetic cardiomyopathy; Histopathology; Oxidative stress; Polydatin; Polydatin nanoparticles; Ultrastructure.

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References

    1. Abdel-Moneim A, El-Shahawy A, Yousef AI, Abd El-Twab SM, Essam Elden Z, Taha M (2019) Novel polydatin-loaded chitosan nanoparticles for safe and efficient type 2 diabetes therapy: In silico, in vitro and in vivo approaches. Int J Biol Macromol. https://doi.org/10.1016/j.ijbiomac.2019.11.031 - DOI - PubMed
    1. Bancroft J, Gamble M (2002) Theory and Practice of Histological Techniques 5th Ed. Edinburg Churchill Livingstone Pub, pp. 172-175.
    1. Beutler E, Duron O, Kelly BM (1963) Improved method for the determination of blood glutathione. J Lab Clin Med 61:882–888 - PubMed
    1. Bozzola JJ, Russell LD (1999) Electron Microscopy: Principles and Techniques for Biologists, 2nd edn. Jones and Bartlett publishers, Boston, p 670
    1. Chen C, Huang K, Hao J, Huang J, Yang Z, Xiong F, Liu P, Huang H (2016) Polydatin attenuates AGEs-induced upregulation of fibronectin and ICAM-1 in rat glomerular mesangial cells and db/db diabetic mice kidneys by inhibiting the activation of the SphK1-S1P signaling pathway. Mol Cell Endocrinol 427:45–56 - PubMed - DOI

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