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. 1988 Feb;14(2):297-300.
doi: 10.1016/0360-3016(88)90436-1.

From 2 Gy to 1 Gy per fraction: sparing effect in rat spinal cord?

E van der Schueren  1 , W Landuyt, K K Ang, A J van der Kogel
Affiliations

From 2 Gy to 1 Gy per fraction: sparing effect in rat spinal cord?

E van der Schueren et al. Int J Radiat Oncol Biol Phys. 1988 Feb.

Abstract

Recently published results, from this group, on rat cervical spinal cord, a late responding tissue, indicated no further sparing with lowering the fraction size from 2 to 1.8, 1.5, and 1.3 Gy. In the present experiments a small but probably significant rise in tolerance is suggested, when the dose per fraction was decreased from 2 Gy down to 1 Gy. This rise would however still be much less than what is predicted by the linear quadratic model, based on the experimental data obtained with fraction sizes larger than 2 Gy.

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