Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Jan;48(1):927-939.
doi: 10.1007/s11033-020-06081-3. Epub 2021 Jan 3.

Unfolding Nrf2 in diabetes mellitus

Tapan Behl  1 , Ishnoor Kaur  2 , Aayush Sehgal  2 , Eshita Sharma  2 , Arun Kumar  2 , Madhuri Grover  3 , Simona Bungau  4
Affiliations
Review

Unfolding Nrf2 in diabetes mellitus

Tapan Behl et al. Mol Biol Rep. 2021 Jan.

Abstract

In spite of much awareness, diabetes mellitus continues to remain one of major reasons for mortality and morbidity rate all over the globe. Free radicals cause oxidative stress which is responsible for causing diabetes. The recent advancements in elucidation of ARE/keap1/Nrf2 pathway can help in better understanding of diabetes mellitus. Various clinical trials and animal studies have shown the promising effect of Nrf2 pathway in reversing diabetes by counteracting with the oxidative stress produced. The gene is known to dissociate from Keap1 on coming in contact with such stresses to show preventive and prognosis effect. The Nrf2 gene has been marked as a molecular player in dealing with wide intracellular as well as extracellular cellular interactions in different diseases. The regulation of this gene gives some transcription factor that contain antioxidant response elements (ARE) in their promoter region and thus are responsible for encoding certain proteins involved in regulation of metabolic and detoxifying enzymes.

Keywords: Hyperglycaemia; Nrf2/Keap1/ACE; Oxidative stress; Reactive oxygen species; Type II diabetes mellitus.

PubMed Disclaimer

References

    1. Tan SM, de Haan JB (2014) Combating oxidative stress in diabetic complications with Nrf2 activators: how much is too much? Redox Rep 19(3):107–117. https://doi.org/10.1179/1351000214Y.0000000087 - DOI - PubMed - PMC
    1. Dieleman JL, Baral R, Birger M, Bui AL, Bulchis A et al (2016) US spending on personal health care and public health, 1996–2013. JAMA 316(24):2627–2646. https://doi.org/10.1001/jama.2016.16885 - DOI - PubMed - PMC
    1. Whiting DR, Guariguata L, Weil C, Shaw J (2011) IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract 94(3):311–321. https://doi.org/10.1186/s13104-016-1896-7 - DOI - PubMed
    1. Schaffer SW, Jong CJ, Mozaffari M (2012) Role of oxidative stress in diabetes-mediated vascular dysfunction: unifying hypothesis of diabetes revisited. Vasc Pharmacol 57(5–6):139–149. https://doi.org/10.1016/j.vph.2012.03.005 - DOI
    1. Sporn MB, Liby KT (2012) NRF2 and cancer: the good, the bad and the importance of context. Nat Rev Cancer 12(8):564–571. https://doi.org/10.1038/nrc3278 - DOI - PubMed

MeSH terms

LinkOut - more resources