Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2021;17(5):e190721189769.
doi: 10.2174/1573403X16999201231203405.

AMI and Anabolic-Androgenic Steroids: Case Report with Systematic Review

Eliana M Mustafa  1 , Idiberto José Zotarelli Filho  1 , Victor R R Ferreira  1 , Sofia Braile Sabino  1 , Giovanni B Sternieri  1 , Luiza B Verdi  1 , Cibele O V Queiroz  1 , Bethina C Sbardellini  1 , Maria C V B Braile-Sternieri  1
Affiliations
Case Reports

AMI and Anabolic-Androgenic Steroids: Case Report with Systematic Review

Eliana M Mustafa et al. Curr Cardiol Rev. 2021.

Abstract

Introduction: Coronary artery disease (CAD) represents approximately 390 thousand deaths per year in Brazil and is associated, among other predictors, with the use of anabolic and androgenic steroids (AAS).

Objective: To analyze a clinical case of a patient who suffered AMI after abuse of AAS. A systematic literature review has been carried out to physiologically analyze the main factors that can lead to AMI with the use of these hormones.

Methods: The EVR patient, 41 years old, denies any comorbidities or use of medications. He has been admitted to the emergency room due to typical angina-precordial pain in tightness associated with eventual back pain and paresthesia of both upper limbs, after intense physical effort at the gym, without improvement at rest, and with partial improvement after first care at the health unit. The patient was hypertensive in an emergency bed after the occurrence of ST elevation. The patient alleges the use of anabolic steroids for one month. The patient presented with obstructive atherosclerotic coronary artery disease with total occlusion of the anterior descending artery. Systematic review: A total of 89 clinical studies have been compared and submitted to eligibility analysis, with 50 studies selected, according to the PRISMA rules.

Results: Long-term consumption of AAS may cause pathological changes, however, AAS can increase protein synthesis, muscle growth, and erythropoiesis.

Conclusion: Abuse of AAS has a toxic cardiovascular effect, which significantly increases the incidence of cardiovascular diseases.

Keywords: Anabolic-androgenic steroids; EVR.; acute myocardial infarction; angioplasty; atherosclerosis; cardiovascular disease.

PubMed Disclaimer

Figures

Fig. (1)
Fig. (1)
Electrocardiogram results showing ventricular tachycardia and ST-elevation before and after treatment of the patient. (A higher resolution / colour version of this figure is available in the electronic copy of the article).
Fig. (2)
Fig. (2)
Image of catheterization in the left anterior descending artery before stent placement. (A higher resolution / colour version of this figure is available in the electronic copy of the article).
Fig. (3)
Fig. (3)
Image of angioplasty in the left anterior descending artery with stent placement. (A higher resolution / colour version of this figure is available in the electronic copy of the article).
See this image and copyright information in PMC

References

    1. World Health Organization (WHO). The top 10 causes of death. Available from: http://www. who.int/mediacentre/factsheets/fs310/en/accessed in 09/10/2019.
    1. IBGE- Instituto Brasileiro de Geografia e Estatística. Available from: http://www.ibge.gov.br.
    1. Flo F.J., Kanu O., Teleb M., Chen Y., Siddiqui T. Anabolic androgenic steroid-induced acute myocardial infarction with multiorgan failure. Proc. Bayl. Univ. Med. Cent. 2018;31(3):334–336. doi: 10.1080/08998280.2018.1460130. - DOI - PMC - PubMed
    1. Shamloul R.M., Aborayah A.F., Hashad A., Abd-Allah F. Anabolic steroids abuse-induced cardiomyopathy and ischaemic stroke in a young male patient. BMJ Case Rep. 2014;2014:bcr2013203033. doi: 10.1136/bcr-2013-203033. - DOI - PMC - PubMed
    1. O’Sullivan A.J., Kennedy M.C., Casey J.H., Day R.O., Corrigan B., Wodak A.D. Anabolic-androgenic steroids: medical assessment of present, past and potential users. Med. J. Aust. 2000;173(6):323–327. doi: 10.5694/j.1326-5377.2000.tb125667.x. - DOI - PubMed