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. 2021 Jan 1;18(2):528-533.
doi: 10.7150/ijms.50966. eCollection 2021.

Prevalence and prognosis of synchronous distant metastatic tonsil squamous cell carcinomas

Yujiao Li  1   2 , Chaosu Hu  1   2
Affiliations

Prevalence and prognosis of synchronous distant metastatic tonsil squamous cell carcinomas

Yujiao Li et al. Int J Med Sci. .

Abstract

Background: To analyze the prevalence proportions and prognostic factors of synchronous distant metastases in patients with tonsil squamous cell carcinomas (TSCC).

Methods: TSCC patients were extracted from the Surveillance, Epidemiology and End Results (SEER) database between 2010 and 2014. We examined the association between clinical manifestations and distant metastases using Chi-squared tests. Predictors of 5-year survival were assessed using univariate and multivariate analyses.

Results: A total of 6193 patients were analyzed and lung was the most common site of distant metastases. Poorly/undifferentiated differentiation was found to be significantly correlated with lung metastasis (p=0.033) and liver and bone metastases were associated with African American (p=0.000 and p=0.000, respectively). A higher T classification was associated with higher prevalence of lung, liver, bone and brain metastasis (p=0.000, p=0.000, p=0.000 and p=0.007, respectively). The same results were found in N classification in lung, liver, and bone metastasis (p=0.000, p=0.000, and p=0.000, respectively). Worse prognosis was associated with older age, Blacks, lower grade, higher T and N classification, no surgery therapy and more metastatic sites.

Conclusion: Lung was the most frequent lesion of synchronous distant metastases and liver and bone metastases were associated with African American. Higher T and N classification were independent prognostic parameters for higher prevalence of lung, bone, liver and brain metastasis. Worse prognosis was associated with older age, African Americans, lower grade, higher T and N classification, no surgery therapy and more metastatic sites.

Keywords: metastatic pattern; prevalence; prognosis; synchronous distant metastases; tonsil squamous cell carcinomas.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Distribution of tumor stages.
Figure 2
Figure 2
Kaplan-Meier analysis of overall survival and cancer-specific survival in localized, regional and metastatic tonsil squamous cell carcinomas patients. A, overall survival in localized, regional and metastatic tonsil squamous cell carcinomas patients (P < 0.05). B, cancer-specific survival in localized, regional and metastatic tonsil squamous cell carcinomas patients (P < 0.05).
See this image and copyright information in PMC

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