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Meta-Analysis
. 2020 Dec 17:11:513073.
doi: 10.3389/fendo.2020.513073. eCollection 2020.

Association Between Perioperative Glycemic Control Strategy and Mortality in Patients With Diabetes Undergoing Cardiac Surgery: A Systematic Review and Meta-Analysis

Xinye Jin  1   2   3 , Jinjing Wang  1   4 , Yanfang Ma  5   6   7 , Xueqiong Li  1   8 , Ping An  1 , Jie Wang  1   9 , Wenfeng Mao  1   9 , Yiming Mu  1 , Yaolong Chen  5   6   7 , Kang Chen  1
Affiliations
Meta-Analysis

Association Between Perioperative Glycemic Control Strategy and Mortality in Patients With Diabetes Undergoing Cardiac Surgery: A Systematic Review and Meta-Analysis

Xinye Jin et al. Front Endocrinol (Lausanne). .

Abstract

Objective: To analyze association between different perioperative glycemic control strategies and postoperative outcomes in patients with diabetes undergoing cardiac surgery.

Methods: MEDLINE, Cochrane Library, Web of Science, EMBASE, Wanfang Data, China National Knowledge Infrastructure (CNKI) and China Biology Medicine (CBM) databases were searched from inception to January 31, 2019. Two researchers independently screened the literature, extracted data, and evaluated the risk of bias of included studies, and consensus was reached by discussion with a third researcher.

Results: Six RCTs were included in the meta-analysis. We analyzed the effect of liberal (>180 mg/dl or 10.0 mmol/L), moderate (140-180 mg/dl or 7.8-10.0 mmol/L) and strict (<140 mg/dl or 7.8 mmol/L) glycemic control strategies in patients with diabetes undergoing cardiac surgery. The pooled results showed that strict glycemic control strategy was associated with a significant reduction in the risk of atrial fibrillation [OR = 0.48, 95%CI (0.32, 0.72), P < 0.001] and sternal wound infection [OR = 0.28, 95%CI (0.14, 0.54), P < 0.001], while there was no significant differences in postoperative mortality, stroke, and hypoglycemic episodes when compared with moderate control. In addition, there is no significant difference between moderate and liberal glycemic control strategies in postoperative mortality. However, moderate control was beneficial in reducing atrial fibrillation [OR = 0.28, 95%CI (0.13, 0.60), P = 0.001] compared with the liberal glycemic control strategy.

Conclusions: This meta-analysis showed when compared with moderate glycemic control strategy in patients with diabetes undergoing cardiac surgery, maintained strict glycemic control was associated with lower risk of atrial fibrillation and sternal wound infection. No benefit was found with liberal glycemic control strategy, so it could be a poor glycemic control strategy.

Keywords: cardiac surgery; diabetes; meta-analysis; perioperative glycemic control; systematic review.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram illustrating the process of identifying articles for selection.
Figure 2
Figure 2
Forest plot for postoperative mortality between perioperative strict and moderate glycemic control strategy.
Figure 3
Figure 3
Forest plot for postoperative stroke between perioperative strict and moderate glycemic control strategy.
Figure 4
Figure 4
Forest plot for postoperative atrial fibrillation between perioperative strict and moderate glycemic control strategy.
Figure 5
Figure 5
Forest plot for postoperative sternal wound infection between perioperative strict and moderate glycemic control strategy.
Figure 6
Figure 6
Forest plot for postoperative hypoglycemic episodes between perioperative strict and moderate glycemic control strategy.
See this image and copyright information in PMC

References

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