Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Dec 22:8:e10390.
doi: 10.7717/peerj.10390. eCollection 2020.

The relationship between anti-Müllerian hormone (AMH) levels and pregnancy outcomes in patients undergoing assisted reproductive techniques (ART)

Shalini Umarsingh #  1 , Jamila Khatoon Adam  1 , Suresh Babu Naidu Krishna #  1
Affiliations

The relationship between anti-Müllerian hormone (AMH) levels and pregnancy outcomes in patients undergoing assisted reproductive techniques (ART)

Shalini Umarsingh et al. PeerJ. .

Abstract

A variety of predictors are available for ovarian stimulation cycles in assisted reproductive technology (ART) forecasting ovarian response and reproductive outcome in women including biomarkers such as anti- Müllerian hormone (AMH). The aim of our present study was to compare the relationship between AMH levels and pregnancy outcomes in patients undergoing intra-cytoplasmic sperm injection (ICSI). Overall, fifty patients (n = 50), aged 20-45 years were recruited for the present prospective study. Three AMH levels were presented with high often poly cystic ovarian syndrome (PCOS) amongst 52.4% patients, 40.5% in normal and 7.1% in low to normal, correspondingly. There was statistically significant relationship between AMH and day of embryo transfer (p < 0.05). The Pearson analysis between AMH, age, E2 and FSH displayed no statistically significant relationship between E2 and AMH (p < 0.05) and negative correlation between FSH and age (p > 0.05). The area under the receiver operating characteristic curve for E2 was 0.725 and for AMH levels as predictors of CPR was 0.497 indicating E2 as better predictor than AMH. The number of oocytes, mature oocytes and fertilized oocytes all presented a weak positive relationship to AMH. Our results confirm the clinical significance of AMH to accurately predict ovarian reserve as a marker and its limitations to use as predictor for a positive pregnancy outcome. Additional prospective studies should be conducted to validate the predictive capability of AMH levels for the outcome of clinical pregnancy.

Keywords: Anti-Müllerian hormone; Clinical pregnancy rate; Enzyme-linked immunosorbent assay; Fertilization in vitro; Oocytes; Pregnancy.

PubMed Disclaimer

Conflict of interest statement

The authors declare there are no competing interests.

Figures

Figure 1
Figure 1. Number of patients associated with pregnancies in relevant age groups.
Figure 2
Figure 2. Sensitivity and specificity of E2 and AMH in predicting pregnancy.
See this image and copyright information in PMC

References

    1. Alson SSE, Bungum LJ, Giwercman A, Henic E. Anti-müllerian hormone levels are associated with live birth rates in ART, but the predictive ability of anti-müllerian hormone is modest. European Journal of Obstetrics, Gynecology and Reproductive Biology. 2018;225:199–204. doi: 10.1016/j.ejogrb.2018.04.039. - DOI - PubMed
    1. Anderson RA, Nelson SM, Wallace WHB. Measuring anti-Müllerian hormone for the assessment of ovarian reserve: when and for whom is it indicated? Maturitas. 2012;71:28–33. doi: 10.1016/j.maturitas.2011.11.008. - DOI - PubMed
    1. Caroppo E, Matteo M, Schonauer IM, Vizziello G, Pasquadibisceglie A, Vitti A, Damato G. Basal FSH concentration as a predictor of IVF outcome in older women undergoing stimulation with GnRH antagonist. Reproductive Biomedicine Online. 2006;13:815–820. doi: 10.1016/S1472-6483(10)61029-2. - DOI - PubMed
    1. Chang MY, Chiang CH, T’sang-T’ang Hsieh MD, Soong YK, Hsu KH. Use of the antral follicle count to predict the outcome of assisted reproductive technologies. Fertility and Sterility. 1998;69:505–510. doi: 10.1016/S0015-0282(97)00557-8. - DOI - PubMed
    1. Dehghani FR, Tayebi N, Asgharnia M. Serum level of anti-mülerian hormone in early follicular phase as a predictor of ovarian reserve and pregnancy outcome in assisted reproductive technology cycles. Archives of Iranian Medicine. 2008;11:371–376. - PubMed

LinkOut - more resources