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Case Reports
. 2020 Dec 26;8(24):6456-6464.
doi: 10.12998/wjcc.v8.i24.6456.

Synchronous colonic mucosa-associated lymphoid tissue lymphoma found after surgery for adenocarcinoma: A case report and review of literature

Juan-Juan Li  1 , Bing-Chen Chen  2 , Jie Dong  3 , Yuan Chen  4 , You-Wei Chen  5
Affiliations
Case Reports

Synchronous colonic mucosa-associated lymphoid tissue lymphoma found after surgery for adenocarcinoma: A case report and review of literature

Juan-Juan Li et al. World J Clin Cases. .

Abstract

Background: Mucosa-associated lymphoid tissue (MALT) lymphoma is a subtype of non-Hodgkin lymphoma that is mainly involved in the gastrointestinal tract. The synchronous occurrence of colonic MALT lymphoma and adenocarcinoma in the same patient is extremely rare. We here report a case of synchronous colonic MALT lymphoma found on surveillance colonoscopy five months after surgery and chemotherapy for sigmoid adenocarcinoma.

Case summary: A 67-year-old man was admitted because of hematochezia for two months. Colonoscopy suggested a colonic tumor before hospitalization. Abdominal computed tomography (CT) revealed local thickening of the sigmoid colon. The patient underwent a left hemicolectomy with local lymph node dissection. The histopathology revealed moderately differentiated adenocarcinoma and partially mucinous adenocarcinoma. The pTNM stage was T3N1Mx. The patient received chemotherapy with six cycles of mFOLFOX6 after surgery. Colonoscopy was performed five months later and revealed single, flat, polypoid lesions of the colon 33 cm away from the anus. Subsequently, the patient underwent endoscopic mucosal resection for further diagnosis. The pathological diagnosis was MALT lymphoma. Positron emission tomography /CT suggested metastasis. The patient refused further treatment and died ten months later.

Conclusion: Colonic MALT lymphoma may occur after surgery and chemotherapy for adenocarcinoma as a synchronous malignancy. Regular surveillance colonoscopy and careful monitoring after surgery are critical.

Keywords: Adenocarcinoma; Case report; Colon; Mucosa-associated lymphoid tissue lymphoma; Surgery; Synchronous malignancy.

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Conflict of interest statement

Conflict-of-interest statement: The authors have declared that no conflicts of interest exist.

Figures

Figure 1
Figure 1
Colonoscopy. A: A 1.2 cm × 0.8 cm flat polypoid lesion in the colon; B: The lesion after submucosal injection of normal saline into the colon.
Figure 2
Figure 2
Histopathological findings. A: Hematoxylin and eosin (HE) staining (× 40); B: HE staining (× 100); C: HE staining (× 200); D: HE staining (× 400).
Figure 3
Figure 3
Immunohistochemical staining (× 100). A: Immunostaining for CD19; B: Immunostaining for CD20; C: Immunostaining for CD21 (dendritic cells); D: Immunostaining for CD23 (dendritic cells); E: Immunostaining for CD43; F: Immunostaining for CD79a; G: Immunostaining for BCL-2; H: Immunostaining for Ki67 (10% positive).
Figure 4
Figure 4
Immunohistochemical staining (× 100). A: Immunostaining for CD3; B: Immunostaining for CD5; C: Immunostaining for CD10; D: Immunostaining for Cyclin D1; E: Immunostaining for kappa; F: Immunostaining for lambda; G: Immunostaining for BCL-6; H: Immunostaining for EBER.
Figure 5
Figure 5
Whole-body maximum intensity projection 18F-fluorodeoxyglucose and positron emission tomography. A: Slightly increased fluorodeoxyglucose metabolism in the subcapsular effusion of the liver, as well as in the right upper area of the peritoneum; B: Positron emission tomography; C: Computed tomography; D: Positron emission tomography/computed tomography in axial projection showing lesions in the subcapsular effusion of the liver.
See this image and copyright information in PMC

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References

    1. Psyrri A, Papageorgiou S, Economopoulos T. Primary extranodal lymphomas of stomach: clinical presentation, diagnostic pitfalls and management. Ann Oncol. 2008;19:1992–1999. - PMC - PubMed
    1. Jaffe ES, Swerdlow SH CE, Campo E, Pileri S, Thiele J, Stein HT, Harris NL, Wardiman JW. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed. Lyon, France: IARC Press, 2008.
    1. A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin's lymphoma. The Non-Hodgkin's Lymphoma Classification Project. Blood. 1997;89:3909–3918. - PubMed
    1. Abbas H, Niazi M, Makker J. Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma of the Colon: A Case Report and a Literature Review. Am J Case Rep. 2017;18:491–497. - PMC - PubMed
    1. Velu AR, Srinivasamurthy BC, Nagarajan K, Sinduja I. Colonic adenocarcinoma, mucosa associated lymphoid tissue lymphoma and tuberculosis in a segment of colon: A case report. World J Gastrointest Oncol. 2014;6:377–380. - PMC - PubMed

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