Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Nov 12;1(6):1341-1348.
doi: 10.1002/emp2.12313. eCollection 2020 Dec.

Multicenter registry of United States emergency department patients tested for SARS-CoV-2

Jeffrey A Kline  1 , Katherine L Pettit  1 , Christopher Kabrhel  2 , D Mark Courtney  3 , Kristen E Nordenholz  4 , Carlos A Camargo  2
Affiliations

Multicenter registry of United States emergency department patients tested for SARS-CoV-2

Jeffrey A Kline et al. J Am Coll Emerg Physicians Open. .

Abstract

This paper summarizes the methodology for the registry of suspected COVID-19 in emergency care (RECOVER), a large clinical registry of patients from 155 United States (US) emergency departments (EDs) in 27 states tested for SARS-CoV-2 from March-September 2020. The initial goals are to derive and test: (1) a pretest probability instrument for prediction of SARS-CoV-2 test results, and from this instrument, a set of simple criteria to exclude COVID-19 (the COVID-19 Rule-Out Criteria-the CORC rule), and (2) a prognostic instrument for those with COVID-19. Patient eligibility included any ED patient tested for SARS-CoV-2 with a nasal or oropharyngeal swab. Abstracted clinical data included 204 variables representing the earliest manifestation of infection, including week of testing, demographics, symptoms, exposure risk, past medical history, test results, admission status, and outcomes 30 days later. In addition to the primary goals, the registry will provide a vital platform for characterizing the course, epidemiology, clinical features, and prognosis of patients tested for COVID-19 in the ED setting.

Keywords: COVID‐19; SARS‐CoV‐2; decision making; diagnosis; probability; prognosis; pulmonary embolism; registries; risk; venous thromboembolism; venous thrombosis.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Diagram of administrative and scientific oversight of the RECOVER registry and network
FIGURE 2
FIGURE 2
Diagram of data flow for the RECOVER registry
FIGURE 3
FIGURE 3
Timeline of eligibility and follow‐up. The index visit refers to the first ED visit that occurred within the previous 14 days of SARS‐CoV‐2 testing. In many cases, the index visit is the same as the day of testing (day 0). All patients are followed for outcomes up to 30 days after the day of SARS‐CoV‐2 testing
See this image and copyright information in PMC

References

    1. U.S. Department of Health & Human Services CfDC. Coronavirus Disease 2019 (COVID‐19). https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/cases-in-us.html. Published 2020. Accessed October 8, 2020.
    1. Lipsitch M, Swerdlow DL, Finelli L. Defining the Epidemiology of Covid‐19 ‐ Studies Needed. N Engl J Med. 2020;382(13):1194–1196. - PubMed
    1. Peirlinck M, Linka K, Sahli Costabal F, et al. Visualizing the invisible: the effect of asymptomatic transmission on the outbreak dynamics of COVID‐19. medRxiv. 2020. - PMC - PubMed
    1. Grassly NC, Pons‐Salort M, Parker EPK, White PJ, Ferguson NM. Comparison of molecular testing strategies for COVID‐19 control: a mathematical modelling study. Lancet Infect Dis. 2020;S1473‐3099(20):30630–30637. - PMC - PubMed
    1. Grubaugh ND, Hanage WP, Rasmussen AL. Making sense of mutation: what D614G means for the COVID‐19 pandemic remains unclear. Cell. 2020;182(4):794–795. - PMC - PubMed