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Review
. 2021 Jan;37(1):1-15.
doi: 10.1007/s00383-020-04781-2. Epub 2021 Jan 3.

Nutritional and pharmacological strategy in children with short bowel syndrome

Michael E Höllwarth  1 , Valeria Solari  2
Affiliations
Review

Nutritional and pharmacological strategy in children with short bowel syndrome

Michael E Höllwarth et al. Pediatr Surg Int. 2021 Jan.

Abstract

Short bowel syndrome in neonates is a severe and life-threatening disease after a major loss of small bowel with or without large bowel. Intestinal adaptation, by which the organism tries to restore digestive and absorptive capacities, is entirely dependent on stimulation of the active enterocytes by enteral nutrition. This review summarizes recent knowledge about the pathophysiologic consequences after the loss of different intestinal parts and outlines the options for enteral nutrition and pharmacological therapies to support the adaptation process.

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References

    1. Aunsholt et al (2014) Bovine colostrum to children with short bowel syndrome: a randomized, double-blind, crossover pilot study. J Parenter Enter Nutr 38:99–106 - DOI
    1. Ben Lulu S et al (2012) Oral insulin stimulates intestinal epithelial cell turnover following massive small bowel resection in a rat and a cell culture model. Pediatr Surg Int 28:179–187 - PubMed - DOI
    1. Berg JK et al (2014) A randomized, double-blind, placebo-controlled, multiple dose, ptallel-group clinical trial to assess the effects of teduglutide on gastric emptying of liquids in healthy subjects. BMC Gstroenterol 14:1–9
    1. Bianchetti DGAM et al (2018) D-lactic acidosis in humans: systematic literature review. Pediatr Nephrol 33:673–681 - PubMed - DOI
    1. Bines J et al (1998) Reducing parenteral requirement in children with short bowel syndrome: impact of amino acid-based complete infant formula. JPGN 26:123–128 - PubMed

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