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Review
. 2021 Aug;40(8):3329-3333.
doi: 10.1007/s10067-020-05559-6. Epub 2021 Jan 3.

A maternal death due to the intracerebral hemorrhage caused by antiphospholipid syndrome: a case report

Bijan Keikhaei  1 , Najmieh Saadati  2 , Mohammad-Reza Mahmoudian-Sani  1 , Mehran Varnaseri  3
Affiliations
Review

A maternal death due to the intracerebral hemorrhage caused by antiphospholipid syndrome: a case report

Bijan Keikhaei et al. Clin Rheumatol. 2021 Aug.

Abstract

Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by the presence of antiphospholipid antibodies in patients with arterial or venous thrombosis or pregnancy complications. This paper reports a case of a 31-year-old woman who died after she underwent C-section for intrauterine fetal death (IUFD) at the 25th week of gestation. The patient was complaining of pelvic pressure, swelling in the lower limbs, and pain in the groin, one big toe, and both wrists. She had low platelet count, liver abnormalities, and proteinuria. After IUFD, she complained of flank pain and headache. After discharge from the hospital, the patient had constant headaches and 5 days later woke up with hemiplegia. CT scan showed cerebral hemorrhage in the right hemisphere and thrombosis in the left hemisphere. The LA and APS tests were positive. The main cause of death was hemorrhage and infarction in the brain.

Keywords: Antiphospholipid syndrome; Beta-2-glycoprotein I; Intracerebral hemorrhage; Lupus anticoagulant.

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