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. 2021 Apr;11(4):814-817.
doi: 10.1002/alr.22731. Epub 2021 Jan 3.

Two-stage genome-wide association study of chronic rhinosinusitis and disease subphenotypes highlights mucosal immunity contributing to risk

Marcus Soliai  1 , Agnes S Sundaresan  2 , Andréanne Morin  1 , Annemarie G Hirsch  2 , Catherine Stanhope  1 , Jordan Kuiper  3 , Brian S Schwartz  2   3 , Carole Ober  1 , Jayant M Pinto  4
Affiliations

Two-stage genome-wide association study of chronic rhinosinusitis and disease subphenotypes highlights mucosal immunity contributing to risk

Marcus Soliai et al. Int Forum Allergy Rhinol. 2021 Apr.
No abstract available

Keywords: Chronic Rhinosinusitis; Rhinosinusitis; Statistics.

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Figures

FIGURE 1
FIGURE 1
CRS GWAS results. (A) Manhattan plot showing chromosome positions along the x axis and –log(p value) on the y axis. The horizontal blue line indicates suggestive significance (p < 1 × 10−5). The closest gene to the sentinel SNP at each locus reaching suggestive significance is shown. (B) Description of the 6 sentinel SNPs in regions reaching suggestive significance. CRS = chronic rhinosinusitus; GWAS = genome‐wide association studies; SNP = single‐nucleotide polymorphism.
FIGURE 2
FIGURE 2
Associations of sentinel SNPs with LCA‐defined subtypes. (A) Associations between 2 LCA‐defined subtypes based on computed tomography scans. Each subtype is compared with the “no/mild opacification” group (n = 191). The p values are corrected for 6 tests. Rows show the sentinel SNPs at each suggestive significant GWAS locus, and its association with each of the subtypes. Results of multinomial logistic regression models, including surgical status, sex, and physician‐diagnosed patient‐reported allergic rhinitis as covariates, are shown for an additive model. Significant SNPs and results are shown in bold. The LocusZoom plots for the 2 significant SNPs in (A) are shown in (B) (rs11068795) and (C) (rs10820254). The SNPs are shown in a ±1‐Mb window with chromosome and gene positions shown on the x axis and the −log10 of the p value and the recombination rate (CMMb) are shown on the left and right y axis, respectively. SNPs are colored according to the estimated linkage disequilibrium (r 2) relative to each lead SNP (purple diamond) and calculated using the 1000 Genomes European panel. CI = confidence interval; LCA = latent class analysis; RRR = relative risk ratio.
See this image and copyright information in PMC

References

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