Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2020 Dec;112(4):210-213.
doi: 10.32074/1591-951X-104.

Atypical cellular neurothekeoma (ACN) of the elderly: case report and brief review of the literature

Nicoletta D'Alessandris  1 , Andrea Picchetto  2 , Maria Gemma Pignataro  1 , Bruna Cerbelli  1 , Domenico Manzo  3 , Carlo Della Rocca  4 , Giulia d'Amati  1 , Angelina Pernazza  4
Affiliations
Case Reports

Atypical cellular neurothekeoma (ACN) of the elderly: case report and brief review of the literature

Nicoletta D'Alessandris et al. Pathologica. 2020 Dec.

Abstract

Atypical cellular neurothekeoma (ACN) is an aggressive and rare variant of cellular neurothekeoma. Only few cases have been reported in the literature and the biological behavior seems to be uncertain. We describe the case of an ACN presenting on the scalp of an elderly man, emphasizing the cytologic features of malignancy. In addition, we provide a brief overview of the literature and discuss the differential diagnosis with other entities, and the possible diagnostic pitfalls.

Keywords: atypical cellular neurothekeoma; diagnostic pitfalls; scalp elderly.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest

The Authors declare no conflict of interest.

Figures

Figure 1.
Figure 1.
On low-power magnification, a non-polipoid, ulcerated and dermal based proliferation, with fascicles architecture (H-E 2x).
Figure 2.
Figure 2.
In this side of the tumor, the neoplastic cells appear to be spindle and slender with storiform arrangement, similar to classic NT (H-E, Original magnification 10x).
Figure 3.
Figure 3.
At high magnification, in the superficial portion of the tumor, the cells become epithelioid with a high number of atypical mitotic figures (H-E, Original magnification 20x).
Figure 4.
Figure 4.
Infiltration of adipose tissue (H-E, Original magnification 4x).
Figure 5.
Figure 5.
Results of immunohistochemistry: the neoplastic cells are diffusely positive for MITF (A), CD10 (B) and NSE (C) (Original magnification 10X).
See this image and copyright information in PMC

References

    1. Harkin JC, Reed RJ. Atlas of Tumor Pathology: Tumors of the peripheral nervous system. Washington, D.C.: Armed Forces Institute of Pathology; 1969. https://doi.org/10.1002/bjs.1800570721 10.1002/bjs.1800570721 - DOI
    1. Gallager RL, Helwig EB. Neurothekoma: a benign cutaneous tumor of neural origin. Am J Clin Pathol 1980;74:759-64. https://doi.org/10.1093/ajcp/74.6.759 10.1093/ajcp/74.6.759 - DOI - PubMed
    1. Rosati LA, Fratamico FCM, Eusebi V. Cellular neurothekeoma. Appl Pathol 1986;4:186-91. https://doi.org/10.2336/nishinihonhifu.52.879 10.2336/nishinihonhifu.52.879 - DOI - PubMed
    1. Barnhill RL, Mihm MC. Cellular neurothekeoma. A distinctive variant of neurothekeoma mimicking nevomelanocytic tumors. Am J Surg Pathol 1990;14:113-20. https://doi.org/10.1097/00000478-199002000-00002 10.1097/00000478-199002000-00002 - DOI - PubMed
    1. Gill P, Abi Daoud MS. Multiple cellular neurothekeomas in a middle-aged woman including the lower extremity: A case report and review of the current literature. J Cutan Pathol 2019;46:67-73. https://doi.org/10.1111/cup.13366 10.1111/cup.13366 - DOI - PubMed

Publication types

Substances

LinkOut - more resources