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Review
. 2021 Feb;40(1):19-27.
doi: 10.1007/s10930-020-09951-8. Epub 2021 Jan 4.

Update and Potential Opportunities in CBP [Cyclic Adenosine Monophosphate (cAMP) Response Element-Binding Protein (CREB)-Binding Protein] Research Using Computational Techniques

Oluwayimika E Akinsiku  1 , Opeyemi S Soremekun  1 , Mahmoud E S Soliman  2
Affiliations
Review

Update and Potential Opportunities in CBP [Cyclic Adenosine Monophosphate (cAMP) Response Element-Binding Protein (CREB)-Binding Protein] Research Using Computational Techniques

Oluwayimika E Akinsiku et al. Protein J. 2021 Feb.

Abstract

CBP [cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB)-binding protein] is one of the most researched proteins for its therapeutic function. Several studies have identified its vast functions and interactions with other transcription factors to initiate cellular signals of survival. In cancer and other diseases such as Alzheimer's, Rubinstein-taybi syndrome, and inflammatory diseases, CBP has been implicated and hence an attractive target in drug design and development. In this review, we explore the various computational techniques that have been used in CBP research, furthermore we identified computational gaps that could be explored to facilitate the development of highly therapeutic CBP inhibitors.

Keywords: Bromodomains; CREB; CREB inhibitors; Molecular dynamic simulation.

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Conflict of interest statement

All authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
CBP and its interacting domains
Fig. 2
Fig. 2
Classification of the different classes of BET Proteins (prepared by the author)
Fig. 3
Fig. 3
A database report from STRING showing the functional interactions of CREBBP with other proteins
Fig. 4
Fig. 4
2D Structures of CREB inhibitors (as prepared by the author)
See this image and copyright information in PMC

References

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