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Meta-Analysis
. 2020 Nov-Dec;14(6):2177-2183.
doi: 10.1016/j.dsx.2020.11.006. Epub 2020 Nov 11.

The Effect of Metformin Consumption on Mortality in Hospitalized COVID-19 patients: a systematic review and meta-analysis

Antonia Anna Lukito  1 , Raymond Pranata  2 , Joshua Henrina  3 , Michael Anthonius Lim  4 , Sherly Lawrensia  5 , Ketut Suastika  6
Affiliations
Meta-Analysis

The Effect of Metformin Consumption on Mortality in Hospitalized COVID-19 patients: a systematic review and meta-analysis

Antonia Anna Lukito et al. Diabetes Metab Syndr. 2020 Nov-Dec.

Abstract

Background and aims: Diabetes is one of the most common comorbidities, and it is associated with poorer outcomes in patients with coronavirus disease 2019 (COVID-19). Preliminary findings showed that mortality was reduced in those who consume metformin compared to those who did not, and given its low cost and widespread availability; metformin is an attractive and potential agent to mitigate excessive risk in diabetic populations.

Methods: Several medical databases (Pubmed, EuropePMC, EBSCOhost, Proquest, Cochrane library) and two health-science preprint servers (preprint.org and Medrxiv) were systematically searched for relevant literature.

Results: Nine studies with 10,233 subjects were included in the qualitative and quantitative synthesis. Meta-analysis showed that metformin is associated with lower mortality in pooled non-adjusted model (OR 0.45 [0.25, 0.81], p = 0.008; I2: 63.9%, p = 0.026) and pooled adjusted model (OR 0.64 [0.43, 0.97], p = 0.035; I2: 52.1%, p = 0.064).

Conclusion: The analysis showed that metformin consumption was associated with lower mortality. Randomized controlled trials are needed to confirm this finding.

Keywords: COVID-19; Diabetes melitus; Metformin; Mortality; SARS-CoV-2.

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Figures

Fig. 1
Fig. 1
PRISMA flow diagram.
Fig. 2
Fig. 2
Metformin consumption and mortality in hospitalized adult COVID-19 patients; Pooled non-adjusted model.
Fig. 3
Fig. 3
Metfomin consumption and mortality in hospitalized adult COVID-19 patients; Pooled adjusted model.
Fig. 4
Fig. 4
Inverted funnel plot analysis The inverted funnel plot analysis showed a symmetrical funnel plot, which indicates no publication bias.
See this image and copyright information in PMC

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