Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2020 Dec 31;13(1):136.
doi: 10.3390/nu13010136.

Quality of Life in Women Diagnosed with Breast Cancer after a 12-Month Treatment of Lifestyle Modifications

Concetta Montagnese  1 , Giuseppe Porciello  1 , Sara Vitale  1 , Elvira Palumbo  1 , Anna Crispo  1 , Maria Grimaldi  1 , Ilaria Calabrese  2 , Rosa Pica  1 , Melania Prete  1 , Luca Falzone  1 , Massimo Libra  3 , Serena Cubisino  4 , Luigina Poletto  5 , Valentina Martinuzzo  5 , Sergio Coluccia  1 , Nadia Esindi  6 , Flavia Nocerino  1 , Anita Minopoli  7 , Bruna Grilli  7 , Pasqualina C Fiorillo  7 , Marco Cuomo  7 , Ernesta Cavalcanti  7 , Guglielmo Thomas  8 , Daniela Cianniello  9 , Monica Pinto  10 , Michelino De Laurentiis  9 , Carmen Pacilio  9 , Massimo Rinaldo  9 , Massimiliano D'Aiuto  11 , Diego Serraino  5 , Samuele Massarut  5 , Laura Caggiari  12 , Chiara Evangelista  12 , Agostino Steffan  12 , Francesca Catalano  4 , Giuseppe L Banna  4 , Giuseppa Scandurra  4 , Francesco Ferraù  13 , Rosalba Rossello  13 , Giovanna Antonelli  13 , Gennaro Guerra  14 , Amalia Farina  14 , Francesco Messina  14 , Gabriele Riccardi  2 , Davide Gatti  15 , David J A Jenkins  16   17   18 , Egidio Celentano  1 , Gerardo Botti  19 , Livia S A Augustin  1
Affiliations
Randomized Controlled Trial

Quality of Life in Women Diagnosed with Breast Cancer after a 12-Month Treatment of Lifestyle Modifications

Concetta Montagnese et al. Nutrients. .

Abstract

Healthy lifestyles are associated with better health-related quality of life (HRQoL), favorable prognosis and lower mortality in breast cancer (BC) survivors. We investigated changes in HRQoL after a 12-month lifestyle modification program in 227 BC survivors participating in DEDiCa trial (Mediterranean diet, exercise, vitamin D). HRQoL was evaluated through validated questionnaires: EQ-5D-3L, EORTC-QLQ-C30 and EORTC QLQ-BR23. Baseline changes were tested using analysis of variance. Multiple regression analyses were performed to assess treatment effects on HRQoL. Increases were observed in global health status (p < 0.001), physical (p = 0.003), role (p = 0.002) and social functioning (p < 0.001), body image (p < 0.001), future perspective (p < 0.001), well-being (p = 0.001), and reductions in fatigue (p < 0.001), nausea and vomiting (p = 0.015), dyspnea (p = 0.001), constipation (p = 0.049), financial problems (p = 0.012), sexual functioning (p = 0.025), systematic therapy side effects (p < 0.001) and breast symptoms (p = 0.004). Multiple regression analyses found inverse associations between changes in BMI and global health status (p = 0.048) and between serum 25(OH)D levels and breast symptoms (p = 0.002). A healthy lifestyle treatment of traditional Mediterranean diet and exercise may impact positively on HRQoL in BC survivors possibly through reductions in body weight while vitamin D sufficiency may improve BC-related symptoms. These findings are relevant to BC survivors whose lower HRQoL negatively affects treatment compliance and disease outcomes.

Keywords: breast cancer; lifestyle; mediterranean diet; physical activity; quality of life; vitamin D.

PubMed Disclaimer

Conflict of interest statement

L.S.A.A. is a founding member of the International Carbohydrate Quality Consortium (ICQC) and has received honoraria from the Nutrition Foundation of Italy (NFI), research grants from LILT (a non-profit organization for the fight against cancer) and in-kind research support from Abiogen Pharma, the Almond Board of California (USA), Barilla (Italy), Consorzio Mandorle di Avola (Italy), DietaDoc (Italy), Ello Frutta (Italy), Panificio Giacomo Luongo (Italy), Perrotta (Italy), Roberto Alimentare (Italy), SunRice (Australia). However, no funding that she has received has been involved in the current project. G.L.B. reports personal fees from Janssen-Cilag, personal fees from Boehringer Ingelheim, personal fees from Roche, non-financial support from Bristol-Myers Squibb, non-financial support from AstraZeneca/MedImmune, non-financial support from Pierre Fabre, non-financial support from Ipsen, outside the submitted work. D.G. has received speaking and/or consulting fees from Abiogen Pharma, Amgen, Eli-Lilly, Janssen-Cilag, Merck and Mundipharma. M.P. has received research support from Amgen. G.R. has received research grants from the Barilla Company to his University Department and is member of the scientific advisory boards of the foundation “Barilla Center for Food and Nutrition” and of “Nutrition Foundation of Italy”. D.J.A.J. has received research grants from Saskatchewan & Alberta Pulse Growers Associations, the Agricultural Bioproducts Innovation Program through the Pulse Research Network, the Advanced Foods and Material Network, Loblaw Companies Ltd., Unilever Canada and Netherlands, Barilla, the Almond Board of California, Agriculture and Agri-food Canada, Pulse Canada, Kellogg’s Company, Canada, Quaker Oats, Canada, Procter & Gamble Technical Centre Ltd., Bayer Consumer Care, Springfield, NJ, Pepsi/Quaker, International Nut & Dried Fruit (INC), Soy Foods Association of North America, the Coca-Cola Company (investigator initiated, unrestricted grant), Solae, Haine Celestial, the Sanitarium Company, Orafti, the International Tree Nut Council Nutrition Research and Education Foundation, the Peanut Institute, Soy Nutrition Institute (SNI), the Canola and Flax Councils of Canada, the Calorie Control Council, the Canadian Institutes of Health Research (CIHR), the Canada Foundation for Innovation (CFI) and the Ontario Research Fund (ORF). He has received in-kind supplies for trials as a research support from the Almond board of California, Walnut Council of California, American Peanut Council, Barilla, Unilever, Unico, Primo, Loblaw Companies, Quaker (Pepsico), Pristine Gourmet, Bunge Limited, Kellogg Canada, WhiteWave Foods. He has been on the speaker’s panel, served on the scientific advisory board and/or received travel support and/or honoraria from the Almond Board of California, Canadian Agriculture Policy Institute, Loblaw Companies Ltd., the Griffin Hospital (for the development of the NuVal scoring system), the Coca-Cola Company, EPICURE, Danone, Diet Quality Photo Navigation (DQPN), Better Therapeutics (FareWell), Verywell, True Health Initiative (THI), Heali AI Corp, Institute of Food Technologists (IFT), Soy Nutrition Institute (SNI), Herbalife Nutrition Institute (HNI), Saskatchewan & Alberta Pulse Growers Associations, Sanitarium Company, Orafti, the American Peanut Council, the International Tree Nut Council Nutrition Research and Education Foundation, the Peanut Institute, Herbalife International, Pacific Health Laboratories, Nutritional Fundamentals for Health (NFH), Barilla, Metagenics, Bayer Consumer Care, Unilever Canada and Netherlands, Solae, Kellogg, Quaker Oats, Procter & Gamble, Abbott Laboratories, Dean Foods, the California Strawberry Commission, Haine Celestial, PepsiCo, the Alpro Foundation, Pioneer Hi-Bred International, DuPont Nutrition and Health, Spherix Consulting and WhiteWave Foods, the Advanced Foods and Material Network, the Canola and Flax Councils of Canada, Agri-Culture and Agri-Food Canada, the Canadian Agri-Food Policy Institute, Pulse Canada, the Soy Foods Association of North America, the Nutrition Foundation of Italy (NFI), Nutra-Source Diagnostics, the McDougall Program, the Toronto Knowledge Translation Group (St. Michael’s Hospital), the Canadian College of Naturopathic Medicine, The Hospital for Sick Children, the Canadian Nutrition Society (CNS), the American Society of Nutrition (ASN), Arizona State University, Paolo Sorbini Foundation and the Institute of Nutrition, Metabolism and Diabetes. He received an honorarium from the United States Department of Agriculture to present the 2013 W.O. Atwater Memorial Lecture. He received the 2013 Award for Excellence in Research from the International Nut and Dried Fruit Council. He received funding and travel support from the Canadian Society of Endocrinology and Metabolism to produce mini cases for the Canadian Diabetes Association (CDA). He is a member of the International Carbohydrate Quality Consortium (ICQC). His wife, Alexandra L Jenkins, is a director and partner of INQUIS Clinical Research for the Food Industry, his 2 daughters, Wendy Jenkins and Amy Jenkins, have published a vegetarian book that promotes the use of the foods described here, The Portfolio Diet for Cardiovascular Risk Reduction (Academic Press/Elsevier 2020 ISBN:978-0-12-810510-8) and his sister, Caroline Brydson, received funding through a grant from the St. Michael’s Hospital Foundation to develop a cookbook for one of his studies. He has had close contact with the food industry to produce plant based diets. However, no funding that he has received has been involved in the current project. All other authors declare no competing interests.

Figures

Figure 1
Figure 1
(a) Comparison of participants with high Mediterranean diet adherence (MEDAS score > 7), physically active (>7500 steps/day) and with vitamin D sufficiency (≥30 ng/mL) at baseline and at 12 months; (b) Comparison of participants’ fatty acids and (c) dietary fibers intakes at baseline and 12 months. (**) significance p < 0.001.
Figure 2
Figure 2
Mean changes of EORTC QLQ-C30 (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30) scores from baseline at 12 months. (*) significance p < 0.05; (**) significance p < 0.001.
Figure 3
Figure 3
(a) Mean changes of European ORTC QLQ-BR23 (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Breast 23) scores of participants. (b) Comparison of participants EQ VAS (European Quality of Life Visual Analogue Scale) at baseline and at 12 months. (*) significance p < 0.05; (**) significance p < 0.001.
See this image and copyright information in PMC

References

    1. Bray F., Ferlay J., Soerjomataram I., Siegel R.L., Torre L.A., Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 2018;68:394–424. doi: 10.3322/caac.21492. - DOI - PubMed
    1. Ferlay J., Soerjomataram I., Dikshit R., Eser S., Mathers C., Rebelo M., Parkin D.M., Forman D., Bray F. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int. J. Cancer. 2015;136:E359–E386. doi: 10.1002/ijc.29210. - DOI - PubMed
    1. Dafni U., Tsourti Z., Alatsathianos I. Breast Cancer Statistics in the European Union: Incidence and Survival across European Countries. Breast Care. 2019;14:344–353. doi: 10.1159/000503219. - DOI - PMC - PubMed
    1. Porciello G., Montagnese C., Crispo A., Grimaldi M., Libra M., Vitale S., Palumbo E., Pica R., Calabrese I., Cubisino S., et al. Mediterranean diet and quality of life in women treated for breast cancer: A baseline analysis of DEDiCa multicentre trial. PLoS ONE. 2020;15:e0239803. doi: 10.1371/journal.pone.0239803. - DOI - PMC - PubMed
    1. Balneaves L.G., Van Patten C., Truant T.L.O., Kelly M.T., Neil S.E., Campbell K.L. Breast cancer survivors’ perspectives on a weight loss and physical activity lifestyle intervention. Support. Care Cancer. 2014;22:2057–2065. doi: 10.1007/s00520-014-2185-4. - DOI - PubMed

Publication types

MeSH terms