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Review
. 2021 Jan 4;19(1):1.
doi: 10.1186/s12951-020-00755-7.

Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis

Hamed Nosrati  1 , Reza Aramideh Khouy  2 , Ali Nosrati  3 , Mohammad Khodaei  4 , Mehdi Banitalebi-Dehkordi  5 , Korosh Ashrafi-Dehkordi  5 , Samira Sanami  6 , Zohreh Alizadeh  7   8
Affiliations
Review

Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis

Hamed Nosrati et al. J Nanobiotechnology. .

Abstract

Skin is the body's first barrier against external pathogens that maintains the homeostasis of the body. Any serious damage to the skin could have an impact on human health and quality of life. Tissue engineering aims to improve the quality of damaged tissue regeneration. One of the most effective treatments for skin tissue regeneration is to improve angiogenesis during the healing period. Over the last decade, there has been an impressive growth of new potential applications for nanobiomaterials in tissue engineering. Various approaches have been developed to improve the rate and quality of the healing process using angiogenic nanomaterials. In this review, we focused on molecular mechanisms and key factors in angiogenesis, the role of nanobiomaterials in angiogenesis, and scaffold-based tissue engineering approaches for accelerated wound healing based on improved angiogenesis.

Keywords: Angiogenesis; Chronic wound; Nanobiotechnology; Scaffold; Skin tissue engineering; Wound healing.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Main stages of angiogenesis [–24]. A normal blood vessel (a). Angiogenic substances stimulate the angiogenesis process (b). Invasion of tip cells and lumen formation (c). Maturation of the new formed blood vessel (d)
Fig. 2
Fig. 2
Signaling pathways induced by VEGF receptors following binding to their ligands [–40]
Fig. 3
Fig. 3
The role of ANGPT-1, ANGPT-2 and their receptor (Tie2) in angiogenesis [, , –50]
Fig. 4
Fig. 4
Ions release from incorporated mesoporous BG during the wound healing process [–125]
Fig. 5
Fig. 5
Mechanism of angiogenesis induced by europium hydroxide nanorods
Fig. 6
Fig. 6
Effect of hydrogel scaffolds on diabetic wound healing. a Construction of diabetic wound model in ICR mice; b Wound healing process during 21 days treatment by different scaffolds (PA: PEGDA + sodium alginate, PAB: PEGDA + sodium alginate + BG-NPs, PABC: PEGDA + sodium alginate + copper-containing BG-NPs), DM: Diabetes mellitus wound was used as a control; c Wound closure rates at day 7, 14 and 21. (*p < 0.05 and **p < 0.01.). Reprinted with Permission from [176]
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