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. 2021 Mar;31(3):145-148.
doi: 10.1016/j.tcb.2020.12.002. Epub 2021 Jan 2.

Biomolecular Condensates at the Front: Cell Migration Meets Phase Separation

Ivan de Curtis  1
Affiliations

Biomolecular Condensates at the Front: Cell Migration Meets Phase Separation

Ivan de Curtis. Trends Cell Biol. 2021 Mar.

Abstract

Liquid-liquid phase separation drives the formation of biomolecular condensates (BCs) for the spatiotemporal organization of several cellular processes. Recent evidences indicate that components of plasma-membrane-associated platforms form biomolecular condensates near focal adhesions (FAs), and suggest that phase separation regulates dynamic processes occurring at the front of migrating cells.

Keywords: biomolecular condensates; cell migration; focal adhesions; liquid–liquid phase separation; plasma-membrane-associated platforms.

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