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Review
. 2021 Jun;26(2):135-155.
doi: 10.1007/s10911-020-09475-y. Epub 2021 Jan 4.

Cancer-Associated Fibroblasts in the Breast Tumor Microenvironment

María Belén Giorello  1 , Francisco Raúl Borzone  2 , Vivian Labovsky  2 , Flavia Valeria Piccioni  3 , Norma Alejandra Chasseing  4
Affiliations
Review

Cancer-Associated Fibroblasts in the Breast Tumor Microenvironment

María Belén Giorello et al. J Mammary Gland Biol Neoplasia. 2021 Jun.

Abstract

Years of investigation have shed light on a theory in which breast tumor epithelial cells are under the effect of the stromal microenvironment. This review aims to discuss recent findings concerning the phenotypic and functional characteristics of cancer associated fibroblasts (CAFs) and their involvement in tumor evolution, as well as their potential implications for anti-cancer therapy. In this manuscript, we reviewed that CAFs play a fundamental role in initiation, growth, invasion, and metastasis of breast cancer, and also serve as biomarkers in the clinical diagnosis, therapy, and prognosis of this disease.

Keywords: Biomarkers of CAFs; Breast cancer; Cancer associated fibroblasts; Immunosuppression activity; Pro-tumoral activity.

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