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Review
. 2020 Dec 25;36(12):2707-2718.
doi: 10.13345/j.cjb.200177.

[Progress in lentiviral vector-mediated gene therapy for Alzheimer's disease and Parkinson's disease]

[Article in Chinese]
Derun Xu  1 , Li Liu  2 , Minglin Lang  1
Affiliations
Free article
Review

[Progress in lentiviral vector-mediated gene therapy for Alzheimer's disease and Parkinson's disease]

[Article in Chinese]
Derun Xu et al. Sheng Wu Gong Cheng Xue Bao. .
Free article

Abstract
in English, Chinese

Alzheimer's disease (AD) and Parkinson's disease (PD) are common neurodegenerative diseases in human. The pathogenesis of AD and PD is complex, and the current drugs and surgical treatments have not successfully alleviated or terminated the progression of the diseases. The lentiviral vector (LV) is a retroviral vector. In recent years, LV mediated gene therapy has been a hotspot to study the mechanisms of human disease and clinical drug discovery. This review summarizes the recent progresses in the treatment of AD and PD by the application of LV, and offers a prospect for its application.

阿尔茨海默症 (Alzheimer’s disease，AD) 与帕金森症 (Parkinson’s disease，PD) 是人类常见的神经退行性疾病。AD 与PD 发病机制复杂，目前的药物和外科手术治疗无法缓解或阻止疾病进程。慢病毒载体 (Lentiviral vector，LV) 是一种逆转录病毒载体，由LV 介导的基因治疗已成为当前疾病机制研究、临床药物开发等领域的研究热点。文中综述了近年来LV 应用于AD、PD 治疗的研究进展，并对今后的应用研究前景进行了展望。.

Keywords: Alzheimer’s disease; Parkinson’s disease; gene therapy; lentiviral vector.

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