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. 2021 Jun;41(7):855-860.
doi: 10.1002/pd.5896. Epub 2021 Jan 25.

Abnormal nuchal translucency followed by normal microarray analysis is associated with placental pathology-related complications

Eyal Krispin  1   2   3 , Anya Kushnir  3 , Asaf Shemer  2 , Shlomit Rienstein  4 , Michal Berkenstadt  2   4 , Yoav Yinon  2   3 , Boaz Weisz  2   3
Affiliations

Abnormal nuchal translucency followed by normal microarray analysis is associated with placental pathology-related complications

Eyal Krispin et al. Prenat Diagn. 2021 Jun.

Abstract

Objective: Identify placental pathology-related complications, labor and neonatal outcomes in pregnancies complicated by pathological nuchal translucency (NT) with normal microarray analysis.

Methods: A retrospective study in which all women with singleton pregnancy who demonstrated NT above 3 mm and a normal microarray analysis were matched to women with normal NT and a normal microarray analysis (2013-2019) in a single tertiary academic center. The following placental pathology-related parameters were measured: preeclampsia, oligohydramnios, suspected intrauterine growth restriction, abnormal Doppler studies or small for gestational age (SGA) neonates. The primary outcome was defined as a composite of complications related to placental pathology including preeclampsia and SGA neonate. Secondary outcomes were labor complications and neonatal morbidity.

Results: A total of 185 women were included in the study: of them, 47 presented an abnormal NT (study group) and 138 presented normal NT (controls). Groups did not significantly differ in baseline characteristics. Regarding primary outcome, all placental-related complications frequencies were higher in the study group, with a composite rate of 17.02% versus 6.52% in controls (p = 0.042%). Secondary outcomes did not differ between groups.

Conclusions: Abnormal NT measurement presented in pregnancies with normal fetal microarray analysis is associated with higher rates of placental-related complications.

Keywords: chromosomal microarray analysis; fetus; nuchal translucency; placental complications.

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References

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