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. 2021 Jan 3;9(1):5.
doi: 10.3390/diseases9010005.

Cystatin C, Vitamin D and Thyroid Function Test Profile in Chronic Kidney Disease Patients

Marlene Tapper  1 , Donovan A McGrowder  1 , Lowell Dilworth  1 , Adedamola Soyibo  2
Affiliations

Cystatin C, Vitamin D and Thyroid Function Test Profile in Chronic Kidney Disease Patients

Marlene Tapper et al. Diseases. .

Abstract

Background: The progression of chronic kidney disease (CKD) is concomitant with complications, including thyroid dysfunction, dyslipidemia and cardiovascular diseases. The aim of this study is to determine serum cystatin C levels, and the prevalence of vitamin D deficiency and thyroid dysfunction in CKD patients.

Methods: A cross-sectional study was conducted involving 140 CKD patients (stages 1-5) that were referred to a renal clinic. Demographic data was collected and thyroid function tests, serum 25-OH-vitamin D, cystatin C levels, and routine biochemistry tests were determined using cobas 6000 analyzer.

Results: 129 (92.1%) of CKD patients had elevated serum cystatin C levels and there was a stepwise increase from stage 1-5. Overt hypothyroidism was present in one patient and nine had subclinical hypothyroidism. There was a stepwise reduction in serum 25-OH-vitamin D levels from stage 2-5, 31 (22.1%) had vitamin D insufficiency and 31 (22.1%) presented with deficiency.

Conclusions: 25-OH-vitamin D deficiency and thyroid disorders are exhibited in chronic kidney disease patients and the severity of the former rises with disease progression, as indicated by elevated cystatin C levels. Routine screening and timely intervention is recommended so as to reduce the risk of cardiovascular diseases.

Keywords: chronic; cystatin C; deficiency; disease; insufficiency; kidney; prevalence; thyroid; vitamin D.

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Conflict of interest statement

The authors of this manuscript declared no potential conflicts of interest with respect to the authorship, research, and/or publication of this article.

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