Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jan 2;11(1):60.
doi: 10.3390/diagnostics11010060.

The Association between Dynamic Changes in Serum Presepsin Levels and Mortality in Immunocompromised Patients with Sepsis: A Prospective Cohort Study

Jongmin Lee  1 , Seohyun Kim  1 , Kyung Hoon Kim  2 , Na Ri Jeong  1 , Seok Chan Kim  1 , Eun-Jee Oh  3
Affiliations

The Association between Dynamic Changes in Serum Presepsin Levels and Mortality in Immunocompromised Patients with Sepsis: A Prospective Cohort Study

Jongmin Lee et al. Diagnostics (Basel). .

Abstract

Presepsin is a subtype of soluble CD14 that is increased in the blood of septic patients. We investigated the role of dynamic changes in serum presepsin levels in critically ill, immunocompromised patients with sepsis. This is a prospective cohort study that included 119 adult patients admitted to the intensive care unit (ICU). Presepsin level was measured on day 1 and day 3 after ICU admission. The primary outcome was in-hospital mortality. In immunocompromised patients, presepsin levels on day 1 were higher in patients with sepsis than those in patients without sepsis. The area under the curve (AUC) of presepsin for diagnosing sepsis in immunocompromised patients was 0.87, which was comparable with that of procalcitonin (AUC, 0.892). Presepsin levels on day 3 were higher in patients who died in the hospital than in those who survived. In immunocompromised patients who died in the hospital, presepsin levels on day 3 were significantly higher than those on day 1. In the multivariate analysis, ΔPresepsin+ alone was independently correlated with in-hospital mortality in immunocompromised patients. These findings suggest that dynamic changes in presepsin levels between day 1 and day 3 are associated with in-hospital mortality in patients with sepsis, especially in immunocompromised patients.

Keywords: immunocompromised; presepsin; sepsis.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Comparison of presepsin value in different pathological conditions. (A) Presepsin value in all patients. (B) Presepsin value in immunocompromised patients. (C) Procalcitonin value in all patients. (D) Procalcitonin value in immunocompromised patients.
Figure 2
Figure 2
Pairwise comparison of receiver operating characteristic (ROC) curves of presepsin and procalcitonin level on the day of ICU admission (A) in all patients and (B) in immunocompromised patients.
Figure 3
Figure 3
Change of presepsin and procalcitonin levels in non-survivors. (A) Presepsin levels in all patients with sepsis. (p = 0.046), (B) Presepsin levels in immunocompromised patients (p = 0.018), (C) Procalcitonin levels in all patients (p = 0.475), and (D) Procalcitonin levels in immunocompromised patients (p = 0.745).
See this image and copyright information in PMC

References

    1. Singer M., Deutschman C.S., Seymour C.W., Shankar-Hari M., Annane D., Bauer M., Bellomo R., Bernard G.R., Chiche J.D., Coopersmith C.M., et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) JAMA. 2016;315:801–810. doi: 10.1001/jama.2016.0287. - DOI - PMC - PubMed
    1. Shozushima T., Takahashi G., Matsumoto N., Kojika M., Okamura Y., Endo S. Usefulness of presepsin (sCD14-ST) measurements as a marker for the diagnosis and severity of sepsis that satisfied diagnostic criteria of systemic inflammatory response syndrome. J. Infect. Chemother. 2011;17:764–769. doi: 10.1007/s10156-011-0254-x. - DOI - PubMed
    1. Kirkland T.N., Viriyakosol S. Structure-function analysis of soluble and membrane-bound CD14. Prog. Clin. Biol. Res. 1998;397:79–87. - PubMed
    1. Camussi G., Mariano F., Biancone L., De Martino A., Bussolati B., Montrucchio G., Tobias P.S. Lipopolysaccharide binding protein and CD14 modulate the synthesis of platelet-activating factor by human monocytes and mesangial and endothelial cells stimulated with lipopolysaccharide. J. Immunol. 1995;155:316–324. - PubMed
    1. Chenevier-Gobeaux C., Bardet V., Poupet H., Poyart C., Borderie D., Claessens Y.E. Presepsin (sCD14-ST) secretion and kinetics by peripheral blood mononuclear cells and monocytic THP-1 cell line. Ann. Biol. Clin. (Paris) 2016;74:93–97. doi: 10.1684/abc.2015.1112. - DOI - PubMed

LinkOut - more resources