Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jan-Feb;35(1):401-410.
doi: 10.21873/invivo.12271.

Sarcopenia may Influence the Prognosis in Advanced Thyroid Cancer Patients Treated With Molecular Targeted Therapy

Akihiro Nishiyama  1 , Yukiko Staub  2 , Yukio Suga  2 , Mikiya Fujita  2 , Azusa Tanimoto  3 , Koushiro Ohtsubo  3 , Seiji Yano  3
Affiliations

Sarcopenia may Influence the Prognosis in Advanced Thyroid Cancer Patients Treated With Molecular Targeted Therapy

Akihiro Nishiyama et al. In Vivo. 2021 Jan-Feb.

Abstract

Background/aim: Reportedly, sarcopenia and nutritional status are associated with prognosis in cancer patients. However, data regarding the relationship of these factors with advanced thyroid cancer patients receiving molecular targeted therapy remains scarce. Therefore, we investigated the relationship between nutritional assessment, as well as sarcopenia, and prognosis in patients with advanced thyroid cancer undergoing molecular targeted therapy.

Patients and methods: In this retrospective study, sarcopenia and several markers of nutritional status were assessed in advanced thyroid cancer patients at the Kanazawa University Hospital, before the introduction of molecular targeted therapy.

Results: Advanced thyroid cancer patients with sarcopenia presented a worse prognosis than those without sarcopenia. Additionally, sarcopenia strongly correlated with several markers of nutritional status, such as albumin, prognostic nutrition index, and Glasgow prognostic score.

Conclusion: Sarcopenia could be a prognostic factor in patients with advanced thyroid cancer receiving molecular targeted therapy.

Keywords: Sarcopenia; advanced thyroid cancer patient; molecular targeted therapy; nutritional assessment.

PubMed Disclaimer

Conflict of interest statement

SY obtained a research grant from Eisai Inc. Other Authors have no potential conflicts of interest.

Figures

Figure 1
Figure 1. Overall survival (OS), progression-free survival (PFS), and treatment time (TP) for all patients with advanced thyroid cancer treated with molecular targeted therapy. The Kaplan-Meier curves estimating OS (a), PFS (b), and TP (c) in 23 patients with advanced thyroid cancer.
Figure 2
Figure 2. Overall survival (OS), progression-free survival (PFS), and treatment time (TP) for differentiated thyroid cancer patients treated with molecular targeted therapy. The Kaplan-Meier curves estimating OS (a), PFS (b), and TP (c) in 18 differentiated thyroid cancer patients
Figure 3
Figure 3. The correlation value of sarcopenia and several nutrition indexes. SARC: Sarcopenia; BMI: body mass index; Alb: albumin; PNI: prognostic nutrition index; GPS: Glasgow prognostic score; NLR: neutrophil-to-lymphocyte ratio; PLR: platelet-to-lymphocyte ratio; CAR: CRPalbumin ratio; *p<0.05, **p<0.01, ***p<0.001
Figure 4
Figure 4. The adverse effects unique to the sarcopenia and non-sarcopenia groups
Figure 5
Figure 5. The hematological toxicities do not significantly differ between the sarcopenia group and non-sarcopenia groups. WBC: White blood cell; NEU: neutrophil; PLT: platelet
Figure 6
Figure 6. The non-hematological toxicities do not significantly differ between the sarcopenia and non-sarcopenia groups. AST: Aspirate aminotransferase; ALT: alanine aminotransferase
Figure 7
Figure 7. Complications related to molecular targeted therapy do not significantly differ between the sarcopenia and non-sarcopenia groups
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Incidence rate of thyroid cancer in Japan. 2017. Available at: https://www.env.go.jp/chemi/rhm/h29kisoshiryo/h29kiso-03-07-19.html [Last accessed 31th March 2017]
    1. Prete A, de Souza PB, Censi S, Muzza M, Nucchi N, Sponziello M. Update on fundamental mechanisms of thyroid cancer. Front Endocrinol (Lausanne) 2020;11:102. doi: 10.3389/fendo.2020.00102. - DOI - PMC - PubMed
    1. Brose MS, Nutting CM, Jarzab B, Elisei R, Siena S, Bastholt L, de la Fouchardiere C, Pacini F, Paschke R, Shong YK, Sherman SI, Smith JWA, Chung J, Kappeler C, Peña C, Molnár I, Schlumberger MJ, DECISION Investigators Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial. Lancet. 2014;384(9940):319–328. doi: 10.1016/S0140-6736(14)60421-9. - DOI - PMC - PubMed
    1. Schlumberger M, Tahara M, Wirth LJ, Robinson B, Brose MS, Elisei R, Habra MA, Newbold K, Shah MH, Hoff AO, Gianoukakis AG, Kiyota N, Taylor MH, Kim SB, Krzyzanowska MK, Dutcus CE, de las Heras B, Zhu J, Sherman SI. Lenvatinib versus placebo in radioiodine-refractory thyroid cancer. N Engl J Med. 2015;372(7):621–630. doi: 10.1056/NEJMoa1406470. - DOI - PubMed
    1. Davis L, Welth HG. Increasing incidence of thyroid cancer in the United States, 1973-2002. JAMA. 2006;295(18):2164–2167. doi: 10.1001/jama.295.18.2164. - DOI - PubMed

LinkOut - more resources