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Case Reports
. 2021 Jan 5;8(2):e939.
doi: 10.1212/NXI.0000000000000939. Print 2021 Mar 4.

Evidence for Independent Hepatitis E Virus Replication in the Brain

Evert P M den Drijver  1 , Annemarie E Brouwer  2 , Nathalie E Synhaeve  2 , Janneke P Keijer  2 , Jaco J Verweij  2 , Jean-Luc Murk  2 , Suzan D Pas  2
Affiliations
Case Reports

Evidence for Independent Hepatitis E Virus Replication in the Brain

Evert P M den Drijver et al. Neurol Neuroimmunol Neuroinflamm. .
No abstract available

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Figures

Figure
Figure. HEV PCR Cycle Threshold Values (Serum, CSF, Faeces) and IgG Antibody Index
(A) Course of infection showing HEV RNA PCR cycle threshold values for serum, CSF, and feces and anti-HEV IgG antibody index values, (B) ALT and GGTs in blood vs WBC values in CSF, and (C) the alignment of reference, serum, and CSF sequence fragment with 4 amino acid in-frame deletion (del 733–736, PTPP) in serum and CSF. An additional 8 amino acid in-frame deletion (del 740–747, IRVLPPPS) in CSF. HEV = hepatitis E virus; IgG = immunoglobulin G.
See this image and copyright information in PMC

References

    1. Sari G, van de Garde MDB, van Schoonhoven A, et al. . Hepatitis E virus shows more genomic alterations in cell culture than in vivo. Pathogens 2019;8:255 Available at: mdpi.com/2076-0817/8/4/255. Accessed February 25, 2020. - PMC - PubMed
    1. Purdy MA, Lara J, Khudyakov YE. The hepatitis E virus polyproline region is involved in viral adaptation. PLoS One 2012;7:e35974 Available at: dx.plos.org/10.1371/journal.pone.0035974. Accessed February 25, 2020. - DOI - PMC - PubMed
    1. Debing Y, Ramière C, Dallmeier K, et al. . Hepatitis E virus mutations associated with ribavirin treatment failure result in altered viral fitness and ribavirin sensitivity. J Hepatol 2016;65:499–508. Available at: linkinghub.elsevier.com/retrieve/pii/S0168827816301878. Accessed February 25, 2020. - PubMed
    1. Dalton HR, Kamar N, van Eijk JJJ, et al. . Hepatitis E virus and neurological injury. Nat Rev Neurol 2016;12:77–85. Available at: nature.com/articles/nrneurol.2015.234. Accessed February 25, 2020. - PubMed
    1. Zhou X, Huang F, Xu L, et al. . Hepatitis E virus infects neurons and brains. J Infect Dis 2017;215:1197–1206. Available at: ncbi.nlm.nih.gov/pubmed/28199701. Accessed February 25, 2020. - PubMed

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