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. 2021 Feb;9(2):e1578.
doi: 10.1002/mgg3.1578. Epub 2021 Jan 5.

Two tSNPs in BRIP1 are associated with breast cancer during TDT analysis

Xuefei Li  1 , Zhuo Li  2 , Miao Yang  3 , Yan Luo  3 , Li Hu  3 , Zhi Xiao  3 , Aji Huang  3 , Juan Huang  3
Affiliations

Two tSNPs in BRIP1 are associated with breast cancer during TDT analysis

Xuefei Li et al. Mol Genet Genomic Med. 2021 Feb.

Abstract

Objectives: This study aimed to investigate and confirm the association between 15 single nucleotide polymorphisms of four susceptibility genes (NBS1, TP53, PTEN, and BRIP1) and the susceptibility of breast cancer.

Methods: The genome DNA was extracted from peripheral blood and tumor tissues from one hundred and seventeen core families. 15 SNPs were detected by PCR. The transmission disequilibrium test (TDT) and the Hardy-Weinberg equilibrium (HWE) are used to verify the association between these SNPs and breast cancer. Further correlation between SNPs and certain pathological features of the tumor, including tumor size, location of lymph nodes, pathologic classification, and the stage and subtype of breast cancer, are analyzed by the chi-square test and logistic regression analysis.

Results: Based on TDTs, two SNPs of rs7220719 and rs11871753 in BRIP1 showed a significant association with breast cancer, while the other 13 selected SNPs did not. However, further statistical analysis demonstrated no obvious differentiation in the clinical characteristics of breast cancer between 37 patients with rs7220719 and 80 patients with wild types. Similar results were also found for rs11871753.

Conclusions: The data provided the evidence for the association between two SNPs of BRIP1 and breast cancer, but did not affect certain clinical phenotypes.

Keywords: BRIP1; SNPs; breast cancer; transmission disequilibrium test.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

FIGURE 1
FIGURE 1
The electrophoretogram image of one patient. The orange line stands for the size standard
FIGURE 2
FIGURE 2
The electrophoretogram image of another patient. The orange line stands for the size standard
See this image and copyright information in PMC

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References

    1. Afzaljavan, F. , Chaeichi, T. N. , Rivandi, M. , Zarif, G. S. , Vahednia, E. , Khayami, R. , Abavisani, M. , & Pasdar, A. (2020). The dilemma of TP53 codon 72 polymorphism (rs1042522) and breast cancer risk: A case‐control study and meta‐analysis in the Iranian population. Cell Journal, 22(2), 185–192. - PMC - PubMed
    1. Anoushirvani, A. A. , Aghabozorgi, R. , Ahmadi, A. , Arjomandzadegan, M. , Sahraei, M. , Khalili, S. , Fereydouni, T. , & Khademi, Z. (2018). Association of rs1042522 SNP with clinicopathologic factors of breast cancer patients in the Markazi province of Iran. Open Access Macedonian Journal of Medical Sciences, 6(12), 2277–2282. - PMC - PubMed
    1. Bai, Y. , Wang, W. , Li, S. , Zhan, J. , Li, H. , Zhao, M. , Zhou, X.A. , Li, S. , Li, X. , Huo, Y. , Shen, Q. , Zhou, M. , Zhang, H. , Luo, J. , Sung, P. , Zhu, W.G. , Xu, X. , & Wang, J. (2019). C1QBP Promotes Homologous Recombination by Stabilizing MRE11 and Controlling the Assembly and Activation of MRE11/RAD50/NBS1 Complex. Mol Cell, 75(6), 1299–1314. e6. - PubMed
    1. Chen, F. Y. , Wang, H. , Li, H. , Hu, X. L. , Dai, X. , Wang, S. M. , Yan, G. J. , Jiang, P. L. , Hu, Y. P. , Huang, J. , & Tang, L. L. (2018). Association of single‐nucleotide polymorphisms in monoubiquitinated FANCD2‐DNA damage repair pathway genes with breast cancer in the Chinese population. Technology in Cancer Research & Treatment, 17, 1533033818819841. - PMC - PubMed
    1. Cox, D. G. , Heudel, P.‐E. , Henry, J. , & Pivot, X. (2018). Transmission of breast cancer polygenic risk based on single nucleotide polymorphisms. The Breast, 41, 14–18. - PubMed

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