Editorial

. 2021 Feb;22(3):137-144.

doi: 10.2217/pgs-2020-0173. Epub 2021 Jan 6.

Veterans Affairs Pharmacogenomic Testing for Veterans (PHASER) clinical program

Olivia M Dong^{1

2}, Jill Bates^{1

3}, Catherine Chanfreau-Coffinier⁴, Michael Naglich⁵, Michael J Kelley^{1

6

7}, Laurence J Meyer^{8

9}, Michael Icardi⁸, Jason L Vassy^{10

11}, Peruvemba Sriram¹², Craig William Heise^{13

14}, Salvador Rivas¹³, Maria Ribeiro^{15

16}, Russell Jacobitz¹², Susan Rozelle¹², Jennifer G Chapman⁵, Deepak Voora^{1

2}

Affiliations

¹ Durham VA Health Care System, Durham, NC 27705, USA.
² Department of Medicine, Duke Center for Applied Genomics & Precision Medicine, Duke University School of Medicine, Durham, NC 27708, USA.
³ Division of Practice Advancement & Clinical Education, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
⁴ VA Informatics & Computing Infrastructure (VINCI), Salt Lake City, UT 84148, USA.
⁵ Institute for Medical Research, Durham VA Medical Center, Durham, NC 27705, USA.
⁶ Department of Medicine, Duke University Medical Center, Durham, NC 27708, USA.
⁷ Department of Veterans Affairs, National Oncology Program Office, Office of Specialty Care, Durham, NC 27705, USA.
⁸ Department of Veterans Affairs, Washington, DC 20571, USA.
⁹ Department of Dermatology, University of Utah, UT 84112, USA.
¹⁰ VA Boston Healthcare System, Boston, MA 02130, USA.
¹¹ Harvard Medical School, Boston, MA 02115, USA.
¹² North Florida/South Georgia Veterans Health System, Gainesville, FL 32608, USA.
¹³ Phoenix VA Health Care System, Phoenix, AZ 85012, USA.
¹⁴ The University of Arizona College of Medicine - Phoenix, Phoenix, AZ 85004, USA.
¹⁵ Atlanta VA Medical Center, Atlanta, GA 30033, USA.
¹⁶ Department of Hematology & Medical Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA.

PMID: 33403869
DOI: 10.2217/pgs-2020-0173

Editorial

Veterans Affairs Pharmacogenomic Testing for Veterans (PHASER) clinical program

Olivia M Dong et al. Pharmacogenomics. 2021 Feb.

. 2021 Feb;22(3):137-144.

doi: 10.2217/pgs-2020-0173. Epub 2021 Jan 6.

Authors

Affiliations

¹ Durham VA Health Care System, Durham, NC 27705, USA.
² Department of Medicine, Duke Center for Applied Genomics & Precision Medicine, Duke University School of Medicine, Durham, NC 27708, USA.
³ Division of Practice Advancement & Clinical Education, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
⁴ VA Informatics & Computing Infrastructure (VINCI), Salt Lake City, UT 84148, USA.
⁵ Institute for Medical Research, Durham VA Medical Center, Durham, NC 27705, USA.
⁶ Department of Medicine, Duke University Medical Center, Durham, NC 27708, USA.
⁷ Department of Veterans Affairs, National Oncology Program Office, Office of Specialty Care, Durham, NC 27705, USA.
⁸ Department of Veterans Affairs, Washington, DC 20571, USA.
⁹ Department of Dermatology, University of Utah, UT 84112, USA.
¹⁰ VA Boston Healthcare System, Boston, MA 02130, USA.
¹¹ Harvard Medical School, Boston, MA 02115, USA.
¹² North Florida/South Georgia Veterans Health System, Gainesville, FL 32608, USA.
¹³ Phoenix VA Health Care System, Phoenix, AZ 85012, USA.
¹⁴ The University of Arizona College of Medicine - Phoenix, Phoenix, AZ 85004, USA.
¹⁵ Atlanta VA Medical Center, Atlanta, GA 30033, USA.
¹⁶ Department of Hematology & Medical Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA.

PMID: 33403869
DOI: 10.2217/pgs-2020-0173

Abstract

In 2019, the Veterans Affairs (VA), the largest integrated US healthcare system, started the Pharmacogenomic Testing for Veterans (PHASER) clinical program that provides multi-gene pharmacogenomic (PGx) testing for up to 250,000 veterans at approximately 50 sites. PHASER is staggering program initiation at sites over a 5-year period from 2019 to 2023, as opposed to simultaneous initiation at all sites, to facilitate iterative program quality improvements through Plan-Do-Study-Act cycles. Current resources in the PGx field have not focused on multisite, remote implementation of panel-based PGx testing. In addition to bringing large scale PGx testing to veterans, the PHASER program is developing a roadmap to maximize uptake and optimize the use of PGx to improve drug response outcomes.

Keywords: Veterans Affairs; clinical program; pharmacogenetics; pharmacogenomics; precision medicine; veterans.

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Veterans Affairs Pharmacogenomic Testing for Veterans (PHASER) clinical program

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Veterans Affairs Pharmacogenomic Testing for Veterans (PHASER) clinical program

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