Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jan 6;188(1):25.
doi: 10.1007/s00604-020-04673-1.

Electrochemical sensor based on Prussian blue/multi-walled carbon nanotubes functionalized polypyrrole nanowire arrays for hydrogen peroxide and microRNA detection

Lili Yang  1 , Jiasheng Wang  1 , Haitao Lü  1 , Ni Hui  2
Affiliations

Electrochemical sensor based on Prussian blue/multi-walled carbon nanotubes functionalized polypyrrole nanowire arrays for hydrogen peroxide and microRNA detection

Lili Yang et al. Mikrochim Acta. .

Abstract

A dual-sensing platform is proposed based on multi-walled carbon nanotubes/Prussian blue-functionalized polypyrrole nanowire array (PPY/MWCNTs/PB). Highly aligned PPY nanowire arrays were electrochemically prepared on the surface of glassy carbon electrodes, which were doped with MWCNTs/PB nanocomposites. The nanomaterial combines the characteristics of the PPY nanowires (high conductivity and large specific surface area) and MWCNTs/PB (excellent catalytic performance and intrinsic redox activity). Owing to the nanowire microstructure and outstanding electrical properties, the PPY/MWCNTs/PB nanowire arrays show excellent electrocatalysis of the reduction of hydrogen peroxide and facilitate the construction of a high-performance biosensing platform for microRNA (miRNA). A linear relationship between analytical signal and concentration of hydrogen peroxide and miRNA was obtained in the range 5 to 503 µM (1.4-5.1 mM) and 0.1 pM to 1 nM, and detection limits of 1.7 μM and 33.4 fM, respectively. This new supersensitive sensing platform has broad application prospects of biomolecule and other analyte determination in drug, biomedical, plant protection, and environmental analysis. Prussian blue/multi-walled carbon nanotubes functionalized polypyrrole nanowire arrays (PPY/MWCNTs/PB) were prepared by a facile one-step electrochemical method. PPY/MWCNTs/PB nanowire arrays show excellent electrocatalysis of the reduction of H2O2 and facilitate the construction of a high-performance biosensing platform for microRNA.

Keywords: Electrocatalysis; Electrochemical sensors; Multi-walled carbon nanotubes; Polypyrrole nanowire arrays; Prussian blue.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Wanekaya AK, Chen W, Myung NV, Mulchandani AJE (2010) Nanowire-based Electrochemical Biosensors electroanalysis 18(6):533–550
    1. Jin C, Lu F, Cao X, Yang Z, Yang R (2013) Facile synthesis and excellent electrochemical properties of NiCo2O4 spinel nanowire arrays as a bifunctional catalyst for the oxygen reduction and evolution reaction. J Mater Chem A 1(39):12170
    1. Li Y, Li N, Ge J, Xue Y, Niu W, Chen MI, Du Y, Ma P X, Lei B (2019) Biodegradable thermal imaging-tracked ultralong nanowire-reinforced conductive nanocomposites elastomers with intrinsical efficient antibacterial and anticancer activity for enhanced biomedical application potential. Biomaterials 201:68–76 - PubMed
    1. Guiseppi-Elie A (2010) Electroconductive hydrogels: synthesis, characterization and biomedical applications. Biomaterials 31(10):2701–2716 - PubMed
    1. Da CSCG, Tristan, De La Torre Medina J, Lemaitre M, Piraux LJNRL (2016) Magnetic and magnetoresistive properties of 3D interconnected NiCo nanowire networks. Nanoscale Res Lett 11(1):466

Publication types

LinkOut - more resources