Setting Up an Automated Biomanufacturing Laboratory
- PMID: 33405219
- DOI: 10.1007/978-1-0716-1032-9_5
Setting Up an Automated Biomanufacturing Laboratory
Abstract
Laboratory automation is a key enabling technology for genetic engineering that can lead to higher throughput, more efficient and accurate experiments, better data management and analysis, decrease in the DBT (Design, Build, and Test) cycle turnaround, increase of reproducibility, and savings in lab resources. Choosing the correct framework among so many options available in terms of software, hardware, and skills needed to operate them is crucial for the success of any automation project. This chapter explores the multiple aspects to be considered for the solid development of a biofoundry project including available software and hardware tools, resources, strategies, partnerships, and collaborations in the field needed to speed up the translation of research results to solve important society problems.
Keywords: Hardware; Laboratory automation; Liquid handling; Machine learning; Metabolic engineering; Reproducibility; Software; Standardization; Synthetic biology; Throughput.
References
-
- Si T, Zhao H (2016) A brief overview of synthetic biology research programs and roadmap studies in the United States. Synth Syst Biotechnol 1(4):258–264 - DOI
-
- Khalil AS, Collins JJ (2010) Synthetic biology: applications come of age. Nat Rev Genet 11(5):367–379 - DOI
-
- Smanski MJ, Zhou H, Claesen J et al (2016) Synthetic biology to access and expand nature’s chemical diversity. Nat Rev Microbiol 14(3):135–149 - DOI
-
- Yeow JA, Ng PK, Tan KS et al (2014) Effects of stress, repetition, fatigue and work environment on human error in manufacturing industries. J Appl Sci 14(24):3464–3471. https://doi.org/10.3923/jas.2014.3464.3471 - DOI
-
- Chao R, Mishra S, Si T, Zhao H (2017) Engineering biological systems using automated biofoundries. Metab Eng 42:98–108 - DOI
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