. 2021 Jun;131(6):E1941-E1949.

doi: 10.1002/lary.29343. Epub 2021 Jan 6.

Systemic Bevacizumab for Treatment of Respiratory Papillomatosis: International Consensus Statement

Douglas R Sidell^{1

2}, Karthik Balakrishnan^{1

2}, Simon R Best³, Karen Zur⁴, Julia Buckingham⁵, Alessandro De Alarcon⁶, Fuad M Baroody⁷, Jonathan M Bock⁸, Emily F Boss⁹, Charles M Bower¹⁰, Paolo Campisi¹¹, Sharon F Chen¹², Jeffrey M Clarke¹³, Kevin D Clarke¹⁴, Alejandro Cocciaglia¹⁵, Robin T Cotton⁶, Giselle Cuestas¹⁶, Kara L Davis¹⁷, Victor H DeFago¹⁸, Frederik G Dikkers¹⁹, Ines Dossans²⁰, Walter Florez²¹, Elizabeth Fox²², Aaron D Friedman²³, Nazaneen Grant²⁴, Osama Hamdi²⁵, Norman D Hogikyan²⁶, Kaalan Johnson²⁷, Liane B Johnson²⁸, Romaine F Johnson²⁹, Peggy Kelly³⁰, Adam M Klein³¹, Claire M Lawlor³², Nicolas Leboulanger³³, Alejandro G Levy³⁴, Derek Lam³⁵, Greg R Licameli³⁶, Steve Long³⁷, David G Lott³⁸, Dayse Manrique³⁹, James Scott McMurray⁴⁰, Kara D Meister^{1

2}, Anna H Messner⁴¹, Michael Mohr⁴², Pamela Mudd³², Anthony J Mortelliti⁴³, Daniel Novakovic⁴⁴, Julian Ongkasuwan⁴⁵, Shazia Peer⁴⁶, Krysztof Piersiala⁴⁷, Jeremy D Prager³⁰, Seth M Pransky⁴⁸, Diego Preciado³², Tiffany Raynor⁴⁹, Rico N P M Rinkel⁵⁰, Hugo Rodriguez⁵¹, Verónica P Rodríguez¹⁶, John Russell⁵², María Laura Scatolini⁵¹, Patrick Scheffler¹, David F Smith⁵³, Lee P Smith⁵⁴, Marshall E Smith⁵⁵, Richard J H Smith⁵⁶, Abraham Sorom⁵⁷, Amalia Steinberg⁵⁸, John A Stith⁵⁹, Dana Thompson⁶⁰, Jerome W Thompson⁶¹, Patricio Varela⁶², David R White⁶³, Andre M Wineland⁹, Christina J Yang⁶⁴, Carlton J Zdanski⁶⁵, Craig S Derkay⁶⁶

Affiliations

¹ Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California, U.S.A.
² Aerodigestive and Airway Reconstruction Center, Lucile Packard Children's Hospital Stanford, Stanford, California, U.S.A.
³ Department of Otolaryngology-Head and Neck Surgery, Division of Laryngology, and, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.
⁴ Division of Pediatric Otolaryngology, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A.
⁵ Maternal and Child Health Research Institute, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford University, Stanford, California, U.S.A.
⁶ Department of Otolaryngology, Division of Pediatric Otolaryngology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, U.S.A.
⁷ Section of Otolaryngology-Head and Neck Surgery and Department of Pediatrics, University of Chicago Medicine and The Comer Children's Hospital, Chicago, Illinois, U.S.A.
⁸ Department of Otolaryngology and Communication Sciences, Division of Laryngology and Professional Voice, Medical College of Wisconsin, Milwaukee, Wisconsin, U.S.A.
⁹ Department of Otolaryngology-Head and Neck Surgery and the Department of Health Policy and Management, Division of Pediatric Otolaryngology, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.
¹⁰ Department of Otolaryngology Head and Neck Surgery, Division of Pediatric Otolaryngology, University of Arkansas for Medical Sciences (UAMS), Arkansas Children's Hospital, Little Rock, Alaska, U.S.A.
¹¹ Department of Otolaryngology - Head and Neck Surgery, Hospital for Sick Children, University of Toronto, Toronto, Canada.
¹² Department of Pediatrics, Division of Infectious Diseases, Lucile Packard Children's Hospital Stanford, Stanford, California, U.S.A.
¹³ Department of Medicine, Division of Oncology, Duke Cancer Institute, Duke University School of Medicine, Durham, North Carolina, U.S.A.
¹⁴ Pediatric Otolaryngology, Division of Otolaryngology Head and Neck Surgery, University of British Columbia (UBC, UVIc), Victoria General Hospital, Victoria, British Columbia, Canada.
¹⁵ ENT-Respiratory Endoscopy Department, Garrahan Children's Hospital, Buenos Aires, Argentina.
¹⁶ Respiratory Endoscopy Section, ENT Department, Hospital General de Niños "Dr. Pedro de Elizalde", Buenos Aires, Argentina.
¹⁷ Department of Pediatrics, Division of Pediatric Oncology, Bass Center for Childhood Cancer and Blood Disorders, Stanford University, Stanford, California, U.S.A.
¹⁸ Pediatric Surgery, Sanatorio del Salvador Privado SA, Cordoba, Argentina.
¹⁹ Department of Otorhinolaryngology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
²⁰ Otolaryngology-Head and Neck Surgery, Hospital Pereira Rossell, Montevideo, Uruguay.
²¹ Department of Otolaryngology, Instituto Nacional de Salud del Niño de San Borja, Lima, Peru.
²² Comprehensive Cancer Center, St Jude Children's Research Hospital, Memphis, Tennessee, U.S.A.
²³ Department of Otolaryngology, Head and Neck Surgery, University of Cincinnati School of Medicine, Cincinnati, Ohio, U.S.A.
²⁴ Department of Otolaryngology, Division of Laryngology, Medstar Georgetown University Hospital, Georgetown, Washington, District of Columbia, U.S.A.
²⁵ Howard University College of Medicine, Washington, District of Columbia, U.S.A.
²⁶ Department of Otolaryngology-Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan, U.S.A.
²⁷ University of Washington School of Medicine, Department of Otolaryngology Head and Neck Surgery, Division of Pediatric Otolaryngology, Seattle, Washington, District of Columbia, U.S.A.
²⁸ Department of Surgery, Dalhousie University, Division of Paediatric Otolaryngology-Head and Neck Surgery, IWK Health Centre, Halifax, Nova Scotia, Canada.
²⁹ Department of Otolaryngology-Head and Neck Surgery, University of Texas (UT) Southwestern Medical Center, Dallas, Texas, U.S.A.
³⁰ Department of Otolaryngology, Head and Neck Surgery, Division of Pediatric Otolaryngology, Children's Hospital Colorado affiliated with University of Colorado, Anschutz, Aurora, Colorado, U.S.A.
³¹ Department of Otolaryngology-Head and Neck Surgery, Division of Laryngology, Emory Voice Center, Emory University School of Medicine, Atlanta, Georgia, U.S.A.
³² Department of Otolaryngology, Division of Pediatric Otolaryngology, Children's National Health System, George Washington University School of Medicine, Washington, District of Columbia, U.S.A.
³³ Head and Neck Surgery, Pediatric Otolaryngology, Necker Enfants Malades Hospital, Paris University, Paris, France.
³⁴ Department of Pediatrics, Division of Pediatric Hematology and Oncology, Arnold Palmer Hospital Center for Children's Cancer and Blood Disorders, Orlando Health, Orlando, Florida, U.S.A.
³⁵ Department of Otolaryngology-Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon, U.S.A.
³⁶ Department of Otolaryngology, Boston Children's Hospital, Boston, Massachusetts, U.S.A.
³⁷ Department of Head and Neck Surgery, Kaiser Permanente, Hillsboro, Oregon, U.S.A.
³⁸ Department of Otorhinolaryngology, Division of Laryngology, Mayo Clinic Arizona, Phoenix, Arizona, U.S.A.
³⁹ Department of Otorhinolaryngology, Universidad Federal de Sao Paulo (UNIFESP), Sao Paulo, Brazil.
⁴⁰ Pediatric Otolaryngology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, U.S.A.
⁴¹ Department of Otolaryngology/Head and Neck Surgery, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, U.S.A.
⁴² Department of Hematology, Oncology and Respiratory Medicine, University Hospital Muenster, Muenster, Germany.
⁴³ Department of Otolaryngology-Head and Neck Surgery, State University of New York (SUNY) Upstate Medical University, Syracuse, New York, U.S.A.
⁴⁴ Department of Otolaryngology, Head and Neck Surgery, Central Clinical School, Faculty of Medicine and Health, University of Sydney, The Canterbury Hospital, Sydney, New South Wales, Australia.
⁴⁵ Department of Otolaryngology, Division of Adult and Pediatric Laryngology, Bobby R. Alford Department of Otolaryngology Head and Neck Surgery, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, U.S.A.
⁴⁶ Division of Otorhinolaryngology, University of Cape Town and Red Cross War Memorial Children's Hospital, Cape Town, South Africa.
⁴⁷ Division of Ear, Nose and Throat Diseases, Karolinska Institutet, Karolinksa University Hospital, Stockholm, Sweden.
⁴⁸ Rady Children's Hospital, San Diego, California, U.S.A.
⁴⁹ Department of Otolaryngology, Head and Neck Surgery, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, U.S.A.
⁵⁰ Department of Otolaryngology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
⁵¹ Respiratory Endoscopy Department, Hospital de Pediatria Prof Dr. Juan P. Garrahan, Buenos Aires, Argentina.
⁵² Department of Paediatric Otolaryngology, Children's Health Ireland, Dublin, Ireland.
⁵³ Divisions of Pediatric Otolaryngology, Pulmonary Medicine, and the Sleep Center, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, U.S.A.
⁵⁴ Division of Otolaryngology-Head and Neck Surgery, Pediatric Otolaryngology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York, U.S.A.
⁵⁵ Division of Otolaryngology-Head and Neck Surgery, University of Utah School of Medicine, Salt Lake City, Utah, U.S.A.
⁵⁶ Department of Otolaryngology-Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa, U.S.A.
⁵⁷ Otolaryngology, Head and Neck Surgery, Confluence Health, Wenatchee, Washington, District of Columbia, U.S.A.
⁵⁸ Otolaryngology, Head and Neck Surgery, Alaska Native Medical center, Anchorage, Alaska, U.S.A.
⁵⁹ Department of Otolaryngology-Head and Neck Surgery, Division of Pediatric Otolaryngology, SSM Cardinal Glennon Children's Hospital Medical Center, St. Louis, Missouri, U.S.A.
⁶⁰ Division of Pediatric Otolaryngology Head and Neck Surgery Ann and Robert H Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, U.S.A.
⁶¹ Department of Otolaryngology-Head and Neck Surgery, Division of Pediatric ENT, LeBonheur Children's Hospital, College of Medicine, University of Tennnessee, Memphis, Tennessee, U.S.A.
⁶² Pediatric Surgery Department, Universidad de Chile, Mackenna Children Hospital, Clinica Las Condes Medical center, Santiago, Chile.
⁶³ Division of Pediatric Otolaryngology, Medical University of South Carolina (MUSC) Shawn Jenkins Children's Hospital, Charleston, South Carolina, U.S.A.
⁶⁴ Department of Otolaryngology-Head and Neck Surgery, Albert Einstein College of Medicine, Montefiore Medical Center, Children's Hospital at Montefiore, New York, New York, U.S.A.
⁶⁵ Department of Otolaryngology/Head and Neck Surgery, Division of Pediatric Otolaryngology/Head and Neck Surgery, North Carolina Children's Hospital, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, U.S.A.
⁶⁶ Department of Otolaryngology-Head and Neck Surgery, Eastern Virginia Medical School, Children's Hospital of the King's Daughters, Norfolk, Virginia, U.S.A.

PMID: 33405268
PMCID: PMC9034687
DOI: 10.1002/lary.29343

Systemic Bevacizumab for Treatment of Respiratory Papillomatosis: International Consensus Statement

Douglas R Sidell et al. Laryngoscope. 2021 Jun.

. 2021 Jun;131(6):E1941-E1949.

doi: 10.1002/lary.29343. Epub 2021 Jan 6.

Authors

Affiliations

¹ Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California, U.S.A.
² Aerodigestive and Airway Reconstruction Center, Lucile Packard Children's Hospital Stanford, Stanford, California, U.S.A.
³ Department of Otolaryngology-Head and Neck Surgery, Division of Laryngology, and, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.
⁴ Division of Pediatric Otolaryngology, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A.
⁵ Maternal and Child Health Research Institute, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford University, Stanford, California, U.S.A.
⁶ Department of Otolaryngology, Division of Pediatric Otolaryngology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, U.S.A.
⁷ Section of Otolaryngology-Head and Neck Surgery and Department of Pediatrics, University of Chicago Medicine and The Comer Children's Hospital, Chicago, Illinois, U.S.A.
⁸ Department of Otolaryngology and Communication Sciences, Division of Laryngology and Professional Voice, Medical College of Wisconsin, Milwaukee, Wisconsin, U.S.A.
⁹ Department of Otolaryngology-Head and Neck Surgery and the Department of Health Policy and Management, Division of Pediatric Otolaryngology, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.
¹⁰ Department of Otolaryngology Head and Neck Surgery, Division of Pediatric Otolaryngology, University of Arkansas for Medical Sciences (UAMS), Arkansas Children's Hospital, Little Rock, Alaska, U.S.A.
¹¹ Department of Otolaryngology - Head and Neck Surgery, Hospital for Sick Children, University of Toronto, Toronto, Canada.
¹² Department of Pediatrics, Division of Infectious Diseases, Lucile Packard Children's Hospital Stanford, Stanford, California, U.S.A.
¹³ Department of Medicine, Division of Oncology, Duke Cancer Institute, Duke University School of Medicine, Durham, North Carolina, U.S.A.
¹⁴ Pediatric Otolaryngology, Division of Otolaryngology Head and Neck Surgery, University of British Columbia (UBC, UVIc), Victoria General Hospital, Victoria, British Columbia, Canada.
¹⁵ ENT-Respiratory Endoscopy Department, Garrahan Children's Hospital, Buenos Aires, Argentina.
¹⁶ Respiratory Endoscopy Section, ENT Department, Hospital General de Niños "Dr. Pedro de Elizalde", Buenos Aires, Argentina.
¹⁷ Department of Pediatrics, Division of Pediatric Oncology, Bass Center for Childhood Cancer and Blood Disorders, Stanford University, Stanford, California, U.S.A.
¹⁸ Pediatric Surgery, Sanatorio del Salvador Privado SA, Cordoba, Argentina.
¹⁹ Department of Otorhinolaryngology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
²⁰ Otolaryngology-Head and Neck Surgery, Hospital Pereira Rossell, Montevideo, Uruguay.
²¹ Department of Otolaryngology, Instituto Nacional de Salud del Niño de San Borja, Lima, Peru.
²² Comprehensive Cancer Center, St Jude Children's Research Hospital, Memphis, Tennessee, U.S.A.
²³ Department of Otolaryngology, Head and Neck Surgery, University of Cincinnati School of Medicine, Cincinnati, Ohio, U.S.A.
²⁴ Department of Otolaryngology, Division of Laryngology, Medstar Georgetown University Hospital, Georgetown, Washington, District of Columbia, U.S.A.
²⁵ Howard University College of Medicine, Washington, District of Columbia, U.S.A.
²⁶ Department of Otolaryngology-Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan, U.S.A.
²⁷ University of Washington School of Medicine, Department of Otolaryngology Head and Neck Surgery, Division of Pediatric Otolaryngology, Seattle, Washington, District of Columbia, U.S.A.
²⁸ Department of Surgery, Dalhousie University, Division of Paediatric Otolaryngology-Head and Neck Surgery, IWK Health Centre, Halifax, Nova Scotia, Canada.
²⁹ Department of Otolaryngology-Head and Neck Surgery, University of Texas (UT) Southwestern Medical Center, Dallas, Texas, U.S.A.
³⁰ Department of Otolaryngology, Head and Neck Surgery, Division of Pediatric Otolaryngology, Children's Hospital Colorado affiliated with University of Colorado, Anschutz, Aurora, Colorado, U.S.A.
³¹ Department of Otolaryngology-Head and Neck Surgery, Division of Laryngology, Emory Voice Center, Emory University School of Medicine, Atlanta, Georgia, U.S.A.
³² Department of Otolaryngology, Division of Pediatric Otolaryngology, Children's National Health System, George Washington University School of Medicine, Washington, District of Columbia, U.S.A.
³³ Head and Neck Surgery, Pediatric Otolaryngology, Necker Enfants Malades Hospital, Paris University, Paris, France.
³⁴ Department of Pediatrics, Division of Pediatric Hematology and Oncology, Arnold Palmer Hospital Center for Children's Cancer and Blood Disorders, Orlando Health, Orlando, Florida, U.S.A.
³⁵ Department of Otolaryngology-Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon, U.S.A.
³⁶ Department of Otolaryngology, Boston Children's Hospital, Boston, Massachusetts, U.S.A.
³⁷ Department of Head and Neck Surgery, Kaiser Permanente, Hillsboro, Oregon, U.S.A.
³⁸ Department of Otorhinolaryngology, Division of Laryngology, Mayo Clinic Arizona, Phoenix, Arizona, U.S.A.
³⁹ Department of Otorhinolaryngology, Universidad Federal de Sao Paulo (UNIFESP), Sao Paulo, Brazil.
⁴⁰ Pediatric Otolaryngology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, U.S.A.
⁴¹ Department of Otolaryngology/Head and Neck Surgery, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, U.S.A.
⁴² Department of Hematology, Oncology and Respiratory Medicine, University Hospital Muenster, Muenster, Germany.
⁴³ Department of Otolaryngology-Head and Neck Surgery, State University of New York (SUNY) Upstate Medical University, Syracuse, New York, U.S.A.
⁴⁴ Department of Otolaryngology, Head and Neck Surgery, Central Clinical School, Faculty of Medicine and Health, University of Sydney, The Canterbury Hospital, Sydney, New South Wales, Australia.
⁴⁵ Department of Otolaryngology, Division of Adult and Pediatric Laryngology, Bobby R. Alford Department of Otolaryngology Head and Neck Surgery, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, U.S.A.
⁴⁶ Division of Otorhinolaryngology, University of Cape Town and Red Cross War Memorial Children's Hospital, Cape Town, South Africa.
⁴⁷ Division of Ear, Nose and Throat Diseases, Karolinska Institutet, Karolinksa University Hospital, Stockholm, Sweden.
⁴⁸ Rady Children's Hospital, San Diego, California, U.S.A.
⁴⁹ Department of Otolaryngology, Head and Neck Surgery, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, U.S.A.
⁵⁰ Department of Otolaryngology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
⁵¹ Respiratory Endoscopy Department, Hospital de Pediatria Prof Dr. Juan P. Garrahan, Buenos Aires, Argentina.
⁵² Department of Paediatric Otolaryngology, Children's Health Ireland, Dublin, Ireland.
⁵³ Divisions of Pediatric Otolaryngology, Pulmonary Medicine, and the Sleep Center, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, U.S.A.
⁵⁴ Division of Otolaryngology-Head and Neck Surgery, Pediatric Otolaryngology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York, U.S.A.
⁵⁵ Division of Otolaryngology-Head and Neck Surgery, University of Utah School of Medicine, Salt Lake City, Utah, U.S.A.
⁵⁶ Department of Otolaryngology-Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa, U.S.A.
⁵⁷ Otolaryngology, Head and Neck Surgery, Confluence Health, Wenatchee, Washington, District of Columbia, U.S.A.
⁵⁸ Otolaryngology, Head and Neck Surgery, Alaska Native Medical center, Anchorage, Alaska, U.S.A.
⁵⁹ Department of Otolaryngology-Head and Neck Surgery, Division of Pediatric Otolaryngology, SSM Cardinal Glennon Children's Hospital Medical Center, St. Louis, Missouri, U.S.A.
⁶⁰ Division of Pediatric Otolaryngology Head and Neck Surgery Ann and Robert H Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, U.S.A.
⁶¹ Department of Otolaryngology-Head and Neck Surgery, Division of Pediatric ENT, LeBonheur Children's Hospital, College of Medicine, University of Tennnessee, Memphis, Tennessee, U.S.A.
⁶² Pediatric Surgery Department, Universidad de Chile, Mackenna Children Hospital, Clinica Las Condes Medical center, Santiago, Chile.
⁶³ Division of Pediatric Otolaryngology, Medical University of South Carolina (MUSC) Shawn Jenkins Children's Hospital, Charleston, South Carolina, U.S.A.
⁶⁴ Department of Otolaryngology-Head and Neck Surgery, Albert Einstein College of Medicine, Montefiore Medical Center, Children's Hospital at Montefiore, New York, New York, U.S.A.
⁶⁵ Department of Otolaryngology/Head and Neck Surgery, Division of Pediatric Otolaryngology/Head and Neck Surgery, North Carolina Children's Hospital, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, U.S.A.
⁶⁶ Department of Otolaryngology-Head and Neck Surgery, Eastern Virginia Medical School, Children's Hospital of the King's Daughters, Norfolk, Virginia, U.S.A.

PMID: 33405268
PMCID: PMC9034687
DOI: 10.1002/lary.29343

Abstract

Objectives/hypothesis: The purpose of this study is to develop consensus on key points that would support the use of systemic bevacizumab for the treatment of recurrent respiratory papillomatosis (RRP), and to provide preliminary guidance surrounding the use of this treatment modality.

Study design: Delphi method-based survey series.

Methods: A multidisciplinary, multi-institutional panel of physicians with experience using systemic bevacizumab for the treatment of RRP was established. The Delphi method was used to identify and obtain consensus on characteristics associated with systemic bevacizumab use across five domains: 1) patient characteristics; 2) disease characteristics; 3) treating center characteristics; 4) prior treatment characteristics; and 5) prior work-up.

Results: The international panel was composed of 70 experts from 12 countries, representing pediatric and adult otolaryngology, hematology/oncology, infectious diseases, pediatric surgery, family medicine, and epidemiology. A total of 189 items were identified, of which consensus was achieved on Patient Characteristics (9), Disease Characteristics (10), Treatment Center Characteristics (22), and Prior Workup Characteristics (18).

Conclusion: This consensus statement provides a useful starting point for clinicians and centers hoping to offer systemic bevacizumab for RRP and may serve as a framework to assess the components of practices and centers currently using this therapy. We hope to provide a strategy to offer the treatment and also to provide a springboard for bevacizumab's use in combination with other RRP treatment protocols. Standardized delivery systems may facilitate research efforts and provide dosing regimens to help shape best-practice applications of systemic bevacizumab for patients with early-onset or less-severe disease phenotypes.

Level of evidence: 5 Laryngoscope, 131:E1941-E1949, 2021.

Keywords: Avastin; Systemic bevacizumab; consensus.

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Conflict of interest statement

The authors have no funding, financial relationships, or conflicts of interest to disclose.

References

1. Derkay CS, Bluher AE. Recurrent respiratory papillomatosis: update 2018. Curr Opin Otolaryngol Head Neck Surg 2018;26:421–425. - PubMed
1. Nagel S, Busch C, Blankenburg T, Schütte W. Treatment of respiratory papillomatosis–a case report on systemic treatment with bevacizumab. Pneumologie 2009;63:387–389. - PubMed
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Systemic Bevacizumab for Treatment of Respiratory Papillomatosis: International Consensus Statement

Affiliations

Systemic Bevacizumab for Treatment of Respiratory Papillomatosis: International Consensus Statement

Authors

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

Substances

Supplementary concepts

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Research Materials