Is neutralization of IFN-γ sufficient to control inflammation in HLH?

Stephan Ehl^{1

2}, Tatiana von Bahr Greenwood^{3

4}, Elisabet Bergsten³, Alain Fischer^{5

6

7}, Jan-Inge Henter^{3

4}, Melissa Hines⁸, Kai Lehmberg⁹, Gritta Janka¹⁰, Despina Moshous^{6

11

12}, Kim E Nichols¹³

Affiliations

¹ Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
² Center for Pediatrics, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
³ Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.
⁴ Pediatric Oncology, Theme of Children's Health, Karolinska University Hospital, Stockholm, Sweden.
⁵ Imagine Institute, Paris, France.
⁶ Paediatric Immunology, Haematology and Rheumatology Unit, Hôpital Necker-Enfants Malades, APHP, Paris, France.
⁷ Collège de France, Paris, France.
⁸ Department of Pediatric Medicine, Division of Critical Care, St. Jude Children's Research Hospital, Memphis, Tennessee.
⁹ Department of Pediatric Hematology and Oncology, Division of Pediatric Stem Cell Transplantation and Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
¹⁰ Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
¹¹ Genome Dynamics in the Immune System, Imagine Institute, Paris, France.
¹² Paris-Descartes University, Sorbonne Paris Cité, Paris, France.
¹³ Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Comment

Stephan Ehl et al. Pediatr Blood Cancer. 2021 Mar.

. 2021 Mar;68(3):e28886.

doi: 10.1002/pbc.28886. Epub 2021 Jan 6.

¹ Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
² Center for Pediatrics, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
³ Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.
⁴ Pediatric Oncology, Theme of Children's Health, Karolinska University Hospital, Stockholm, Sweden.
⁵ Imagine Institute, Paris, France.
⁶ Paediatric Immunology, Haematology and Rheumatology Unit, Hôpital Necker-Enfants Malades, APHP, Paris, France.
⁷ Collège de France, Paris, France.
⁸ Department of Pediatric Medicine, Division of Critical Care, St. Jude Children's Research Hospital, Memphis, Tennessee.
⁹ Department of Pediatric Hematology and Oncology, Division of Pediatric Stem Cell Transplantation and Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
¹⁰ Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
¹¹ Genome Dynamics in the Immune System, Imagine Institute, Paris, France.
¹² Paris-Descartes University, Sorbonne Paris Cité, Paris, France.
¹³ Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

No abstract available

Comment on

Emapalumab in Children with Primary Hemophagocytic Lymphohistiocytosis.
Locatelli F, Jordan MB, Allen C, Cesaro S, Rizzari C, Rao A, Degar B, Garrington TP, Sevilla J, Putti MC, Fagioli F, Ahlmann M, Dapena Diaz JL, Henry M, De Benedetti F, Grom A, Lapeyre G, Jacqmin P, Ballabio M, de Min C. Locatelli F, et al. N Engl J Med. 2020 May 7;382(19):1811-1822. doi: 10.1056/NEJMoa1911326. N Engl J Med. 2020. PMID: 32374962 Clinical Trial.

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