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. 2021 Jan;19(1):68-74.
doi: 10.1111/jth.15109.

Recommendations for clinical laboratory testing for protein S deficiency: Communication from the SSC committee plasma coagulation inhibitors of the ISTH

Richard A Marlar  1 , Jana N Gausman  2 , Hiroko Tsuda  3 , Marian A Rollins-Raval  1 , Herm Jan M Brinkman  4
Affiliations
Free article

Recommendations for clinical laboratory testing for protein S deficiency: Communication from the SSC committee plasma coagulation inhibitors of the ISTH

Richard A Marlar et al. J Thromb Haemost. 2021 Jan.
Free article

Abstract

Hereditary deficiencies of protein S (PS) increase the risk of venous thrombosis; however, assessing the plasma levels of PS can be difficult because of its complex physiological interactions in plasma, sample-related preanalytical variables, and numerous acquired disease processes. Reliable laboratory assays are essential for accurate evaluation of PS when diagnosing a congenital deficiency based on the plasma phenotype alone. This report presents the current evidence-based recommendations for clinical PS assays as well as when to test for PS abnormalities.

Keywords: coagulation; laboratory testing; protein S; protein S deficiency.

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References

REFERENCES

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