Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Feb 1;56(2):e98-e108.
doi: 10.1097/MCG.0000000000001482.

Room for Improvement in the Treatment of Helicobacter pylori Infection: Lessons from the European Registry on H. pylori Management (Hp-EuReg)

Olga P Nyssen  1 , Dino Vaira  2 , Bojan Tepes  3 , Limas Kupcinskas  4 , Dmitry Bordin  5 , Ángeles Pérez-Aisa  6 , Antonio Gasbarrini  7 , Manuel Castro-Fernández  8 , Luis Bujanda  9 , Ana Garre  1 , Alfredo Lucendo  10 , Liudmila Vologzhanina  11 , Natasa B Jurecic  12 , Luis Rodrigo-Sáez  13 , Jose M Huguet  14 , Irina Voynovan  5 , Jorge Perez-Lasala  15 , Pilar Mata Romero  16 , Miroslav Vujasinovic  17 , Rustam Abdulkhakov  18 , Jesús Barrio  19 , Luis Fernandez-Salazar  20 , Francis Mégraud  21 , Colm O'Morain  22 , Javier P Gisbert  1
Affiliations

Room for Improvement in the Treatment of Helicobacter pylori Infection: Lessons from the European Registry on H. pylori Management (Hp-EuReg)

Olga P Nyssen et al. J Clin Gastroenterol. .

Abstract

Background: Managing Helicobacter pylori infection requires constant decision making, and each decision is open to possible errors.

Aim: The aim was to evaluate common mistakes in the eradication of H. pylori, based on the "European Registry on Helicobacter pylori management".

Methods: European Registry on Helicobacter pylori management is an international multicentre prospective noninterventional registry evaluating the decisions and outcomes of H. pylori management by European gastroenterologists in routine clinical practice.

Results: Countries recruiting more than 1000 patients were included (26,340 patients). The most common mistakes (percentages) were: (1) To use the standard triple therapy where it is ineffective (46%). (2) To prescribe eradication therapy for only 7 to 10 days (69%). (3) To use a low dose of proton pump inhibitors (48%). (4) In patients allergic to penicillin, to prescribe always a triple therapy with clarithromycin and metronidazole (38%). (5) To repeat certain antibiotics after eradication failure (>15%). (6) Failing to consider the importance of compliance with treatment (2%). (7) Not to check the eradication success (6%). Time-trend analyses showed progressive greater compliance with current clinical guidelines.

Conclusion: The management of H. pylori infection by some European gastroenterologists is heterogeneous, frequently suboptimal and discrepant with current recommendations. Clinical practice is constantly adapting to updated recommendations, although this shift is delayed and slow.

PubMed Disclaimer

References

    1. Gisbert JP, Nyssen OP Probert C. Ten common errors in the treatment of Helicobacter pylori infection. Recent Advances in Gastroenterology. ISBN13: 9781909836242. New Delhi: Jaypee Brothers Medical Publishers Ltd. 2000:106–150.
    1. McNicholl AG, O’Morain CA, Megraud F, et al. Protocol of the European Registry on the management of Helicobacter pylori infection (Hp-EuReg). Helicobacter. 2019;24:e12630.
    1. Fallone CA, Chiba N, van Zanten SV, et al. The Toronto Consensus for the treatment of Helicobacter pylori infection in adults. Gastroenterology. 2016;151:51–69.e14.
    1. Malfertheiner P, Megraud F, O’Morain CA, et al. Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report. Gut. 2017;66:6–30.
    1. Graham DY, Lu H, Dore MP. Relative potency of proton-pump inhibitors, Helicobacter pylori therapy cure rates, and meaning of double-dose PPI. Helicobacter. 2019;24:e12554.

Publication types