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Comment
. 2021 Jan 5;33(1):4-6.
doi: 10.1016/j.cmet.2020.12.012.

Adipocyte Microenvironment: Everybody in the Neighborhood Talks about the Temperature

Farnaz Shamsi  1 , Yu-Hua Tseng  1 , C Ronald Kahn  2
Affiliations
Comment

Adipocyte Microenvironment: Everybody in the Neighborhood Talks about the Temperature

Farnaz Shamsi et al. Cell Metab. .

Abstract

Adipose tissue is composed of a variety of cells distributed in different depots and playing various metabolic roles. In a recent issue of Nature, Sun et al. (2020) use snRNA-seq and functional studies to identify a population of adipocytes that can suppress the thermogenic activity of neighboring adipocytes by secretion of acetate.

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Conflict of interest statement

Declaration of Interests Y.-H.T. and C.R.K. are consultants for Cellarity, a company that employs single-cell and single-nucleus gene expression data to understand tissue metabolism and growth.

Figures

Figure 1.
Figure 1.. Regulation of Thermogenesis by Inter-Adipocyte Communications
Multiple subtypes of adipocytes are present in a single white or brown adipose depot. Signaling peptides, including BMP8b, FGF6, FGF9, FGF21, and SLIT2, released by brown or beige adipocytes function in an autocrine/paracrine manner to promote thermogenesis. In contrast, acetate secreted by the CYP2E1+/ALDH1A1+ adipocytes negatively regulates UCP1 expression in the neighboring thermogenic adipocytes.
See this image and copyright information in PMC

Comment on

  • snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis.
    Sun W, Dong H, Balaz M, Slyper M, Drokhlyansky E, Colleluori G, Giordano A, Kovanicova Z, Stefanicka P, Balazova L, Ding L, Husted AS, Rudofsky G, Ukropec J, Cinti S, Schwartz TW, Regev A, Wolfrum C. Sun W, et al. Nature. 2020 Nov;587(7832):98-102. doi: 10.1038/s41586-020-2856-x. Epub 2020 Oct 28. Nature. 2020. PMID: 33116305

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