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. 2021 Jan 6;21(1):17.
doi: 10.1186/s12876-020-01579-3.

Metabolic syndrome components and acute pancreatitis: a case-control study in China

Zhemin Shen  1 , Xueqiao Wang  2 , Zili Zhen  1 , Yao Wang  3 , Peilong Sun  4
Affiliations

Metabolic syndrome components and acute pancreatitis: a case-control study in China

Zhemin Shen et al. BMC Gastroenterol. .

Abstract

Background: Acute pancreatitis (AP) is a common inflammatory disorder of the pancreas. Recent evidence has shown that metabolic syndrome is positively correlated with the severity of AP. However, only a few studies have revealed the relationship between metabolic syndrome and the occurrence of AP. We therefore elucidated the association between metabolic syndrome and the occurrence of AP.

Methods: A hospital-based case-control study was conducted. A total of 705 patients admitted to our hospital from January 2016 to December 2018 were included in the study. Subjects were divided into case and control groups according to their diagnosis: (1) According to the revised Atlanta classification from 2012, patients diagnosed with AP were enrolled in the case group. (2) Patients without a history of AP or any disease related to metabolic syndrome were allocated into the control group. Controls were matched to cases individually by sex and age (control/case ratio = 1).

Results: The incidence rate of metabolic syndrome in AP patients was 30.9%, which was more frequent than that in controls (13.2%) (OR 2.837; 95% CI 1.873-4.298, p < 0.001). In the multivariate regression analysis, a history of smoking or alcohol consumption and biliary stones were significantly associated with AP (OR 2.441; 95% CI 1.865-5.172, p < 0.001; OR 1.777; 95% CI 1.060-2.977, p = 0.029; OR 28.995; 95% CI 13.253-63.435, p < 0.001). In addition, the occurrence of AP was significantly associated with total cholesterol (TC) (OR 1.992; 95% CI 1.246-3.183, p = 0.004), triglyceride (TG) (OR 2.134; 95% CI 1.403-3.245, p < 0.001), hyperglycaemia (OR 2.261; 95% CI 1.367-3.742, p = 0.001), and apolipoprotein A (Apo A) (OR 0.270; 95% CI 0.163-0.447, p < 0.001).

Conclusions: Metabolic syndrome and its components were associated with AP occurrence.

Keywords: Acute pancreatitis; Hyperglycaemia; Hyperlipidaemia; Hypertension; Metabolic syndrome; Obesity.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Receiver operating characteristic (ROC) curve analysis for predicting the occurrence of AP by TG, Apo A and FPG in the estimation cohorts. AP acute pancreatitis, TG triglyceride, Apo A apolipoprotein A, FPG fasting plasma glucose
Fig. 2
Fig. 2
The number of metabolic syndrome components in relation to the occurrence of AP. AP acute pancreatitis
See this image and copyright information in PMC

References

    1. Sawalhi S, Al-Maramhy H, Abdelrahman AI, Allah SE, Al-Jubori S. Does the presence of obesity and/or metabolic syndrome affect the course of acute pancreatitis? A prospective study. Pancreas. 2014;43(4):565–570. doi: 10.1097/MPA.0000000000000028. - DOI - PubMed
    1. Lowenfels AB, Maisonneuve P, Sullivan T. The changing character of acute pancreatitis: epidemiology, etiology, and prognosis. Curr Gastroenterol Rep. 2009;11(2):97–103. doi: 10.1007/s11894-009-0016-4. - DOI - PubMed
    1. Lankisch PG, Apte M, Banks PA. Acute pancreatitis. Lancet. 2015;386:85–96. doi: 10.1016/S0140-6736(14)60649-8. - DOI - PubMed
    1. Song QB, Zhao Y, Liu YQ, Zhang J, Xin SJ, Dong GH. Sex difference in the prevalence of metabolic syndrome and cardiovascular-related risk factors in urban adults from 33 communities of China: the CHPSNE study. Diabetes Vasc Dis Res. 2015;12(3):189–198. doi: 10.1177/1479164114562410. - DOI - PubMed
    1. Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet. 2005;365(9468):1415–1428. doi: 10.1016/S0140-6736(05)66378-7. - DOI - PubMed