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Meta-Analysis
. 2021 Jun;25(6):4115-4124.
doi: 10.1007/s00784-020-03743-1. Epub 2021 Jan 7.

Clinical applicability of natural products for prevention and treatment of oral mucositis: a systematic review and meta-analysis

Ingrid Carla Guedes da Silva Lima  1 , Laura de Fátima Souto Maior  2 , Luiz Alcino Monteiro Gueiros  2 , Jair Carneiro Leão  2 , Jane Sheila Higino  3 , Alessandra Albuquerque Tavares Carvalho  2
Affiliations
Meta-Analysis

Clinical applicability of natural products for prevention and treatment of oral mucositis: a systematic review and meta-analysis

Ingrid Carla Guedes da Silva Lima et al. Clin Oral Investig. 2021 Jun.

Abstract

Objective: A systematic review and meta-analysis was carried out to verify evidence regarding the efficacy and safety of the clinical applicability of natural products in the prevention and treatment of oral mucositis induced by chemotherapy and/or radiotherapy.

Methodology: An electronic research according to the PICOS strategy, using the terms "natural products" and "oral mucositis," was carried out at Pubmed, Cochrane, Embase, and "gray literature." The stages of eligibility, data extraction, and quality assessment of the studies were carried out independently and in duplicate.

Results: The number of studies identified as eligible was 151, including 47 randomized controlled trials, reporting a total of 3075 participants undergoing some therapy with natural products on oral mucositis. The included clinical trials covered a variety of 31 types of natural products. Considering the risk of bias of the clinical trials, 24 studies (51.1%) were considered to have a low overall risk of bias, nine (19.1%) were at moderate risk, and 14 clinical trials (29.8%) were at high risk of bias. Honey was the most assessed natural agent. Fourteen studies (3.4%) reported that natural agents reduced pain.

Conclusion: The results of the meta-analysis support a positive effect of honey and Aloe vera in reducing mucositis in patients receiving cancer therapy.

Clinical relevance: The results found add relevant information to the scientific community regarding the prevention and treatment of mucositis. Graphical abstract.

Keywords: Chemotherapy; Meta-analysis; Natural products; Oral mucositis; Radiotherapy; Systematic review.

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References

References3

    1. Al-Dasooqi N, Sonis ST, Bowen JM, Bateman E, Blijlevens N, Gibson RJ et al (2013) Emerging evidence on the pathobiology of mucositis. Support Care Cancer 21(11):3233–3241 - PubMed
    1. Scully C, Sonis S, Diz PD (2006) Oral mucositis. Oral Dis 12:229–241 - PubMed
    1. De Sanctis V, Bossi P, Sanguineti G, Trippa F, Ferrari D, Bacigalupo A, Ripamonti CI, Buglione M, Pergolizzi S, Langendjik JA, Murphy B, Raber-Durlacher J, Russi EG, Lalla RV (2016) Mucositis in head and neck cancer patients treated with radiotherapy and systemic therapies: literature review and consensus statements. Crit Rev Oncol Hematol 100:147–166 - PubMed
    1. Vitale KM, Violago L, Cofnas P, Bishop J, Jin Z, Bhatia M, Kung AL, George D, Garvin J, Satwani P (2014) Impact of palifermin on incidence of oral mucositis and healthcare utilization in children undergoing autologous hematopoietic stem cell transplantation for malignant diseases. Pediatr Transplant 18:211–216 - PubMed
    1. Yavuz B, Bal Yılmaz H (2015) Investigation of the effects of planned mouth care education on the degree of oral mucositis in pediatric oncology patients. J Pediatr Oncol Nurs 32(1):47–56 - PubMed

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